A0A143WWV6 · A0A143WWV6_9ACTN

Function

function

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site64Zn2+ (UniProtKB | ChEBI); catalytic
Active site66Proton donor
Binding site94Zn2+ (UniProtKB | ChEBI); catalytic
Binding site97Zn2+ (UniProtKB | ChEBI); catalytic
Active site268
Binding site363-373ATP (UniProtKB | ChEBI)
Active site405

GO annotations

AspectTerm
Molecular Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
Molecular FunctionATP binding
Molecular FunctiontRNA-specific adenosine-34 deaminase activity
Molecular Functionzinc ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process
Biological ProcesstRNA wobble adenosine to inosine editing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
  • EC number
  • Short names
    CMK
  • Alternative names
    • 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
  • Recommended name
    tRNA-specific adenosine deaminase
  • EC number

Gene names

    • Name
      tadA_1
    • Synonyms
      ispE
      , tadA
    • ORF names
      BN3658_00101

Organism names

Accessions

  • Primary accession
    A0A143WWV6

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-140CMP/dCMP-type deaminase
Region163-229Disordered
Compositional bias171-210Polar residues

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    559
  • Mass (Da)
    58,623
  • Last updated
    2016-06-08 v1
  • Checksum
    FB6874E9FC1A7ED2
MTDEDYMRMAIDEARRAERLGEVPIGAVVVYEPIDPATRRSLEKPQVIARACNLRETTKDPAGHAEFLAMKRAAEVLDAWRLTDCTVYVTLEPCVMCAGLMHQARVRRCVYGAADPKAGALGTLYAVNEDKRLNHTFEAVPGVLGGECARMLRDFFSRKRAKKSQKQEAKDMANENGSPSVPVVSETASAAPSRSSTAATSASSAAVSSPAPSAAGAPSAAGASSGGEGSGVGDPCAVDLLDVARVAQQVETERFRGPGSVRVVAPAKVNLFLDIGEVRPDGYHEAVSIMHALLLHDVLHLRLAPAREAGLSVDLTCRSRGGVAPLDVAPEDNIVTKAVRRFAQALERDVDETVAVHVEKRIPAQAGLGGGSSDAAAALVGVARLWGVPEDDPRIEEVARSLGADVPFFLRGGCACFTGVGDVFSHELAPSNACVALIKPEGGVSTSAAYRAFDACPQRIAPADRLAALDARHAADVPLRNNLTVASEQLLPVLAEVRAWASGHADVQAALMSGSGSAVFAVCPSFDAAARVAAQAQARGWWARATMFAPVRAAMVGAR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias171-210Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FCNB01000006
EMBL· GenBank· DDBJ
CVH74888.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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