A0A143WWV6 · A0A143WWV6_9ACTN
- ProteinMultifunctional fusion protein
- GenetadA_1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids559 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Catalytic activity
- 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 64 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 66 | Proton donor | ||||
Sequence: E | ||||||
Binding site | 94 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 97 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Active site | 268 | |||||
Sequence: K | ||||||
Binding site | 363-373 | ATP (UniProtKB | ChEBI) | ||||
Sequence: PAQAGLGGGSS | ||||||
Active site | 405 | |||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | tRNA-specific adenosine-34 deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process | |
Biological Process | tRNA wobble adenosine to inosine editing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended name4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
- EC number
- Short namesCMK
- Alternative names
- Recommended nametRNA-specific adenosine deaminase
- EC number
Gene names
Organism names
- Taxonomic lineageBacteria > Actinomycetota > Coriobacteriia > Coriobacteriales > Coriobacteriaceae
Accessions
- Primary accessionA0A143WWV6
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-140 | CMP/dCMP-type deaminase | ||||
Sequence: MTDEDYMRMAIDEARRAERLGEVPIGAVVVYEPIDPATRRSLEKPQVIARACNLRETTKDPAGHAEFLAMKRAAEVLDAWRLTDCTVYVTLEPCVMCAGLMHQARVRRCVYGAADPKAGALGTLYAVNEDKRLNHTFEAV | ||||||
Region | 163-229 | Disordered | ||||
Sequence: KSQKQEAKDMANENGSPSVPVVSETASAAPSRSSTAATSASSAAVSSPAPSAAGAPSAAGASSGGEG | ||||||
Compositional bias | 171-210 | Polar residues | ||||
Sequence: DMANENGSPSVPVVSETASAAPSRSSTAATSASSAAVSSP |
Sequence similarities
Belongs to the GHMP kinase family. IspE subfamily.
Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length559
- Mass (Da)58,623
- Last updated2016-06-08 v1
- ChecksumFB6874E9FC1A7ED2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 171-210 | Polar residues | ||||
Sequence: DMANENGSPSVPVVSETASAAPSRSSTAATSASSAAVSSP |
Keywords
- Technical term