A0A142KJT6 · A0A142KJT6_9ACTN

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site171(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site175-177(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site282Plays an important role in substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      AXH35_13895

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 55737
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Propionibacteriaceae > Acidipropionibacterium

Accessions

  • Primary accession
    A0A142KJT6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue283N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    488
  • Mass (Da)
    52,637
  • Last updated
    2016-06-08 v1
  • Checksum
    12346D75FF91203F
MPESTYPEPTSINAQAAPAYQTLLDIIGSVEPRIADATRAELHDQRHSLKLIASENYASLPVLATMGTWFSDKYAEGTIGHRFYAGCQNVDTVESVAAEHARELFGAEHAYVQPHSGIDANLTAYWAILAHHVETPALAEFGSKNVNDLSAEDWETLRHRFNDQRAIGMSLDAGGHLTHGFRPNISGKMFNQRSYGTDPQTGLLDYDKVRELAREFKPLVIVAGYSAYPRRVNFAKMREIADEIGAVLMVDMAHFAGLVAGKVFTGDEDPVPNAQVVTTTTHKSLRGPRGGMILVDKEYADDVDRGCPMVLGGPLGHVMAAKAVALAEARTQAFRDYAQKVADNSRALAEGLMKRGVKLVTDGTDNHINLLDVTTSFGLTGRQAESALLDSGIVTNRNSIPADPNGAWYTSGVRIGTPALTSRGFGADEFDRVAALIVEALKATTPKTASTGKPGKAKYEMADGVADRVHAEADELVGSFPLYPGLEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP014352
EMBL· GenBank· DDBJ
AMS06374.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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