A0A142JZA7 · A0A142JZA7_9ORTH
- ProteinNADH-ubiquinone oxidoreductase chain 5
- GeneND5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids137 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Biological Process | ATP synthesis coupled electron transport | |
Biological Process | electron transport coupled proton transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 5
- EC number
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Orthoptera > Ensifera > Tettigoniidea > Rhaphidophoroidea > Rhaphidophoridae > Ceuthophilinae > Ceuthophilus
Accessions
- Primary accessionA0A142JZA7
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 23-45 | Helical | ||||
Sequence: WLGQFLLLISGLTMFMSGLGAMF | ||||||
Transmembrane | 52-70 | Helical | ||||
Sequence: IIALSTLSQLGLMMSTLAM | ||||||
Transmembrane | 76-98 | Helical | ||||
Sequence: AFFHLLTHALFKALLFMCAGAII |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-136 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: STLVTAGVYLLIRFNEIIMSSWLGQFLLLISGLTMFMSGLGAMFEYDLKSIIALSTLSQLGLMMSTLAMGFPKLAFFHLLTHALFKALLFMCAGAIIHNMKNLQDIRGMGGLIQQMPLTSVCLNVSNLALCGMPF |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length137
- Mass (Da)14,958
- Last updated2016-06-08 v1
- Checksum232C58A0BC9B7042
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 137 | |||||
Sequence: L |