A0A142CJ47 · A0A142CJ47_THYAR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A142CJ47

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-52Helical
Transmembrane73-97Helical
Transmembrane117-140Helical
Transmembrane152-179Helical
Transmembrane212-230Helical
Transmembrane237-260Helical
Transmembrane272-295Helical
Transmembrane307-328Helical
Transmembrane348-372Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-394Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    394
  • Mass (Da)
    43,069
  • Last updated
    2016-06-08 v1
  • MD5 Checksum
    593FFFD5D969FA1A6F15B293E6E83FCD
ALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGAFVHWFPLFTGFTLHSTWTKIHFGIMFVGVNLTF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue394

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU867899
EMBL· GenBank· DDBJ
AMQ10424.1
EMBL· GenBank· DDBJ
Genomic DNA
KU867900
EMBL· GenBank· DDBJ
AMQ10425.1
EMBL· GenBank· DDBJ
Genomic DNA
KU867901
EMBL· GenBank· DDBJ
AMQ10426.1
EMBL· GenBank· DDBJ
Genomic DNA
KU867902
EMBL· GenBank· DDBJ
AMQ10427.1
EMBL· GenBank· DDBJ
Genomic DNA
KU867903
EMBL· GenBank· DDBJ
AMQ10428.1
EMBL· GenBank· DDBJ
Genomic DNA
KU867904
EMBL· GenBank· DDBJ
AMQ10429.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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