A0A141R7K3 · A0A141R7K3_SVCV

Function

Catalytic activity

  • GTP + H2O = GDP + H+ + phosphate
  • a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H+ + 2 S-adenosyl-L-homocysteine
    EC:2.1.1.375 (UniProtKB | ENZYME | Rhea)
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H+ + S-adenosyl-L-homocysteine
  • a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
    EC:2.7.7.88 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA-dependent RNA polymerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed RNA polymerase L
  • EC number
  • Alternative names
    • Large structural protein
    • Replicase
    • Transcriptase

Gene names

    • Name
      L

Organism names

Accessions

  • Primary accession
    A0A141R7K3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane825-843Helical
Transmembrane864-886Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain587-773RdRp catalytic
Domain1625-1822Mononegavirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the rhabdoviridae protein L family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,095
  • Mass (Da)
    238,286
  • Last updated
    2016-06-08 v1
  • Checksum
    570A01BAC692A5C9
MFEWESQDTPSGLPDEESYFPTSKLSVEERMHYLNNVDYNLNSPLISDDIEYLTLKHFGRAIPSLWKIKNWEIPLEMLKGVGIIKTWDQIHPWMGRWFDSGHNCPQGESFLRTVQAESELTSEIPVTFIKGWIGKEIKFPVKRGHHAVHLLMQKVLDLHKLTLLINSVDSSETEKLCESFGLNPKQSKFETHSLGTVRYCPGWIFIEKAEILLDRNFLLMMKDTLIGRLQTLLSMLGNCEMEIEQICTHTETMLSLYSYGDQIIEKSGNNGYSKIKLLEPICNLRLSELAHKYRPLVPDFPHFQEHVETSVREEDTPEGLLSAILSLVNNTEDIQLILTIYGSFRHWGHPFISYFEGLQKLHDQVTLPKQIDREYAAALASDLAYTVLQRKFSEEKKWYVDSITLPQKHPLKEHVDNGTWPTAAQIQDFGDRWHLLPLTKCFEVPDLLDPSVIYSDKSHSMNRKEVIDHVISTPNKPIPSKKVLETMINNPATDWPTFLKAVDEEGLPRDSLIIGLKGKERELKIAGRFFSLMSWQLREYFVITEYLIKTHYVPLFKGLTMADDLTSVVKKMLDNTNGQGLDDYSSICIANHIDYEKWNNHQRKESNGPVFRVMGQFLGYPRLFERTHEFFESSLIYYNGRPDLMDVRGDSLVNTTDRIVCWEGQAGGLEGLRQKGWSVLNLLVINRESSIRNTVVKVLAQGDNQVICTQYKTKNYKNEEELIMLLTAMVENNQTIMNGIIAGTGKLGLIINNDETMQSADYLNYGKVPVFRGILRGLETKRWSRVTCITNDQIPTLAGVMSSVSTNALTVAHFAASPINAILQYHYFANFCLMMIAMHNPAIRSSMYTKMFRKCHIMSREFKAVTLYLDPSLGGVCGISLARFLIRSFPDPVTEGLAFWKMIHHNCQSDWLKALSKRCGNPKLARFRPEHIPKIIEDPAALNISMGMSASNLLKTEVKGHLIRTADTIQNQIIREAAEYLGQEEESLNEFLWDIEPFFPRFLSEFRSSTFVGATDSLIGLFQNSKTIRGLFKSYYKRELDRLVVKSELSSLEHLGSYRKETPDSIWECSSTQADLLREKSWGRSVIGMTVPHPLEMFGKGHQKELECIPCQTSGLTYISSYCPKGINNWYSTVGSLAAYLGSKTSETTSILQPWEKDSKIPIIKRATKLRDSISWFVPPDSKLAKSIQQNLKALTGEDWEEDIQGFKRTGSALHRFTTSRVSNGGFSAQSPAKLTRIMTTTDTMRDLGDQNYDFMFQAGILYSQMTTGELRENSTNSTATHYHITCESCLREIQEPMLESRVIYNPPSSSRVIKSWIPNATEIMEESKPVKLREVDWDPLTRYEKSYHIGRCQGFLYGDLTYQKTGRSGESSIFPLSIQYKVEGSGFMRGFCDGIIRASAVQALHRRVSSIVSTADVIYGGALYLTNQVGDSPPFQNLCRSGPLREELERIPHKMTSSYPTSNSDMGYLIRNYLKRSLKQLSRGRYETRDGPIWVFSDVRTKKFLGPFSLSTDALNCLYKNKLSKKDKNAVRNLSQLSSRMRSGDLSDEEIGKIEARFSFTPAEMRHACKFTIGKTQVPIVMSEWGQEAYGNITMYPVFYSTIKTEKPDWTFSRLQNPTISGLRISQQATGAHYKLRSLLKGMKIHYQDAIGCGDGSGGLSSCLLRENKHCRVIFNSLLELTGNTLRGSTPDPPSAINGIPQVRDRCVNLTSVWEHPSDLSHPDTWKYFGELKAQCNMDIDLIVMDMEVQDIDISRRIEQNLRDHVHSLLSRHGTVIYKTYMTILSENERSVLDIVGVLFEDVQLCQTQYSSSQTSEVYCVMRRLRQKVDSQHVDWQSLVRQGINSKVYCNLPLDKEFERALNLYQIDTLVGVPRELIPNLAVELETLLEIGGLSGGILGKLVLNIEEGKLGFTMALIVSCILISESAICTTRLSNKREVPSSGACQRMAVCLIGAAILLSVHHRSIENHKGAIRMLRHSVPIRISSKLRKDGKLQSRWSSISREGLAKDVRLSSNMAGVGAWIRVWSRMKDRERRWEAREADSWLKTNNKGLSMEHVRRHTGVLDILHGTGDRLDRSVPTVSYAPRDFGTWVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR012466
EMBL· GenBank· DDBJ
AMH40151.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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