A novel susceptibility gene ST13 coding for a cochaperone of the glucocorticoid receptor is associated with exacerbations in asthmatic children and young adults despite their ICS use.
Hip has been identified as a novel substrate of GRK5 in vitro and in cells and phosphorylation of Hip by GRK5 plays a role in modulating CXCR4 internalization
A single amino acid substitution (L211S) resulted in a loss of Hip function. This mutation also appears to disrupt the interaction of Hip with Hsp70 in vitro
results suggest that granzyme B-mediated loss of HIP expression occurs in vivo and in a coordinate fashion with loss of BID pro-caspase-8 and pro-caspase-3; data implicate the Hsp70 co-chaperone HIP in the proteolytic cascade of some apoptotic pathways
tetratricopeptide repeat domain is required for effects of CHIP on alpha-synuclein inclusion morphology number of inclusions and proteasomal degradation as well as the direct interaction of CHIP with Hsp70 implicates their cooperation in these processes
The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.