Thermal shift assay to probe melting of thrombin fibrinogen fibrin monomer and fibrin: Gly-Pro-Arg-Pro induces a fibrin monomer-like state in fibrinogen.
Mutations Causing Mild or No Structural Damage in Interfaces of Multimerization of the Fibrinogen gamma-Module More Likely Confer Negative Dominant Behaviors.
Genetic Variants in the FGB and FGG Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype.
Quantitative Serum Proteomic Study Reveals that Fibrinogen-Related Proteins May Participate in the Pathophysiological Process of Simple Febrile Convulsion.
We analyzed the association of a single nucleotide polymorphism (SNP) in rs2066865 in the fibrinogen gamma chain (FGG) gene alteration in plasma fibrinogen concentration and presence of microvascular flap thrombosis.
This study examined the polymerization abilities of the recombinant fibrinogen gamma variants gammaD318Y and gammaK321E. No polymerization was observed for gammaD318Y fibrinogen similar to gammaDeltaN319D320. gammaK321E fibrinogen showed slightly reduced polymerization.
Three new mutations affecting splicing were detected in FGG gene: fibrinogen Poznan II fibrinogen Zakopane and fibrinogen Belchatow. Like in other populations hotspot mutations linked to dysfibrinogenemia were observed in most patients.
Fibrinogen FGA FGB and FGG genes were sequenced in 17 patients by next-generation sequencing. Variants leading to fibrinogen deficiency were found in all patients. Eight novel variants were described.
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