A0A140VJG8 · A0A140VJG8_HUMAN

  • Protein
    Catechol O-methyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Catalytic activity

  • 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H+
    This reaction proceeds in the forward direction.
  • 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H+
    This reaction proceeds in the forward direction.
  • 2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + S-adenosyl-L-homocysteine + H+
    This reaction proceeds in the forward direction.
  • 2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + S-adenosyl-L-homocysteine + H+
    This reaction proceeds in the forward direction.
  • 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H+
    This reaction proceeds in the forward direction.
  • 4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + S-adenosyl-L-homocysteine + H+
    This reaction proceeds in the forward direction.
  • a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H+
    This reaction proceeds in the forward direction.
    EC:2.1.1.6 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site92S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site122S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site140S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site167-170S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site191Mg2+ (UniProtKB | ChEBI)
Binding site191S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site194substrate
Binding site219Mg2+ (UniProtKB | ChEBI)
Binding site220Mg2+ (UniProtKB | ChEBI)
Binding site220substrate
Binding site249substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentplasma membrane
Cellular Componentsynapse
Cellular Componentvesicle
Molecular Functioncatechol O-methyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processartery development
Biological Processbehavioral fear response
Biological Processcellular response to cocaine
Biological Processcellular response to phosphate starvation
Biological Processcerebellar cortex morphogenesis
Biological Processcholesterol efflux
Biological Processdetection of temperature stimulus involved in sensory perception of pain
Biological Processdopamine catabolic process
Biological Processdopamine secretion
Biological Processexploration behavior
Biological Processgene expression
Biological Processglomerulus development
Biological Processglycogen metabolic process
Biological Processhabituation
Biological Processmastication
Biological Processmemory
Biological Processmethylation
Biological Processmulticellular organism growth
Biological Processnorepinephrine metabolic process
Biological Processnorepinephrine secretion
Biological Processprostaglandin metabolic process
Biological Processrenal albumin absorption
Biological Processrenal filtration
Biological Processrenal sodium excretion
Biological Processrenin secretion into blood stream
Biological Processresponse to amphetamine
Biological Processresponse to angiotensin
Biological Processresponse to corticosterone
Biological Processresponse to cytokine
Biological Processresponse to dopamine
Biological Processresponse to food
Biological Processresponse to hypoxia
Biological Processresponse to oxidative stress
Biological Processresponse to salt
Biological Processresponse to toxic substance
Biological Processresponse to wounding
Biological Processresponse to xenobiotic stimulus
Biological Processstartle response
Biological Processsynaptic transmission, dopaminergic
Biological Processvisual learning

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catechol O-methyltransferase
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A140VJG8

Organism-specific databases

Subcellular Location

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    30,037
  • Last updated
    2016-06-08 v1
  • Checksum
    D2547A1C399AC758
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM005355
EMBL· GenBank· DDBJ
AEE60955.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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