A0A140VJG8 · A0A140VJG8_HUMAN
- ProteinCatechol O-methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids271 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Catalytic activity
- 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- 2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- 2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- 4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 92 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 122 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 140 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 167-170 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 191 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 191 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 194 | substrate | |||
Binding site | 219 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 220 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 220 | substrate | |||
Binding site | 249 | substrate | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCatechol O-methyltransferase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A140VJG8
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length271
- Mass (Da)30,037
- Last updated2016-06-08 v1
- ChecksumD2547A1C399AC758
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM005355 EMBL· GenBank· DDBJ | AEE60955.1 EMBL· GenBank· DDBJ | mRNA |