A0A140F7S6 · A0A140F7S6_9CNID
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids152 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Zoantharia > Epizoanthidae > Epizoanthus
Accessions
- Primary accessionA0A140F7S6
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-31 | Helical | |||
Transmembrane | 43-61 | Helical | |||
Transmembrane | 91-114 | Helical | |||
Transmembrane | 126-149 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length152
- Mass (Da)16,258
- Last updated2016-05-11 v1
- MD5 ChecksumA90DC30E22C6D9A5C440B8E5E873BC37
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 152 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU175786 EMBL· GenBank· DDBJ | AML79675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175787 EMBL· GenBank· DDBJ | AML79676.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175788 EMBL· GenBank· DDBJ | AML79677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175789 EMBL· GenBank· DDBJ | AML79678.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175790 EMBL· GenBank· DDBJ | AML79679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175791 EMBL· GenBank· DDBJ | AML79680.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175792 EMBL· GenBank· DDBJ | AML79681.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175793 EMBL· GenBank· DDBJ | AML79682.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175794 EMBL· GenBank· DDBJ | AML79683.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175795 EMBL· GenBank· DDBJ | AML79684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175796 EMBL· GenBank· DDBJ | AML79685.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175797 EMBL· GenBank· DDBJ | AML79686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175798 EMBL· GenBank· DDBJ | AML79687.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175799 EMBL· GenBank· DDBJ | AML79688.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175800 EMBL· GenBank· DDBJ | AML79689.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175802 EMBL· GenBank· DDBJ | AML79691.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175803 EMBL· GenBank· DDBJ | AML79692.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175804 EMBL· GenBank· DDBJ | AML79693.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175805 EMBL· GenBank· DDBJ | AML79694.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175806 EMBL· GenBank· DDBJ | AML79695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175807 EMBL· GenBank· DDBJ | AML79696.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175808 EMBL· GenBank· DDBJ | AML79697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175809 EMBL· GenBank· DDBJ | AML79698.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175810 EMBL· GenBank· DDBJ | AML79699.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175811 EMBL· GenBank· DDBJ | AML79700.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175813 EMBL· GenBank· DDBJ | AML79702.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175816 EMBL· GenBank· DDBJ | AML79705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU175819 EMBL· GenBank· DDBJ | AML79708.1 EMBL· GenBank· DDBJ | Genomic DNA |