A0A140F7S6 · A0A140F7S6_9CNID

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • HK101
    • HK105
    • HK114_2
    • HK23_2
    • HK24_2
  • Taxonomic lineage
    Eukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Zoantharia > Epizoanthidae > Epizoanthus

Accessions

  • Primary accession
    A0A140F7S6

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-31Helical
Transmembrane43-61Helical
Transmembrane91-114Helical
Transmembrane126-149Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-152Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    152
  • Mass (Da)
    16,258
  • Last updated
    2016-05-11 v1
  • MD5 Checksum
    A90DC30E22C6D9A5C440B8E5E873BC37
VTAHAFVMIFFLVMPVMIGGFGNWLVPLYIGAPDMAFPRLNNISFWLLPPALILLLGSAFVEQGVGTGWTVYPPLASIQAHSGGAVDMAIFSLHLAGVSSILGAMNFITTIFNMRAPGVTLDRLPLFVWSILITAFLLLLSLPVLAGGITML

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue152

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU175786
EMBL· GenBank· DDBJ
AML79675.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175787
EMBL· GenBank· DDBJ
AML79676.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175788
EMBL· GenBank· DDBJ
AML79677.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175789
EMBL· GenBank· DDBJ
AML79678.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175790
EMBL· GenBank· DDBJ
AML79679.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175791
EMBL· GenBank· DDBJ
AML79680.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175792
EMBL· GenBank· DDBJ
AML79681.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175793
EMBL· GenBank· DDBJ
AML79682.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175794
EMBL· GenBank· DDBJ
AML79683.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175795
EMBL· GenBank· DDBJ
AML79684.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175796
EMBL· GenBank· DDBJ
AML79685.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175797
EMBL· GenBank· DDBJ
AML79686.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175798
EMBL· GenBank· DDBJ
AML79687.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175799
EMBL· GenBank· DDBJ
AML79688.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175800
EMBL· GenBank· DDBJ
AML79689.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175802
EMBL· GenBank· DDBJ
AML79691.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175803
EMBL· GenBank· DDBJ
AML79692.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175804
EMBL· GenBank· DDBJ
AML79693.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175805
EMBL· GenBank· DDBJ
AML79694.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175806
EMBL· GenBank· DDBJ
AML79695.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175807
EMBL· GenBank· DDBJ
AML79696.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175808
EMBL· GenBank· DDBJ
AML79697.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175809
EMBL· GenBank· DDBJ
AML79698.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175810
EMBL· GenBank· DDBJ
AML79699.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175811
EMBL· GenBank· DDBJ
AML79700.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175813
EMBL· GenBank· DDBJ
AML79702.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175816
EMBL· GenBank· DDBJ
AML79705.1
EMBL· GenBank· DDBJ
Genomic DNA
KU175819
EMBL· GenBank· DDBJ
AML79708.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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