A0A140E067 · A0A140E067_CVHOC

Function

function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell Golgi membrane
Cellular Componentmembrane
Biological Processapoptotic process
Biological Processdisruption of cellular anatomical structure in another organism
Biological Processviral budding from Golgi membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Envelope small membrane protein
  • Short names
    E protein
    ; sM protein

Gene names

    • Name
      E

Organism names

  • Taxonomic identifier
  • Strain
    • HCoV-OC43/UK/London/2011
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Embecovirus > Betacoronavirus 1

Accessions

  • Primary accession
    A0A140E067

Proteomes

Subcellular Location

Host Golgi apparatus membrane
; Single-pass type III membrane protein
Note: The cytoplasmic tail functions as a Golgi complex-targeting signal.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-18Virion surface
Transmembrane12-39Helical
Topological domain40-85Intravirion

Keywords

Interaction

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Family & Domains

Sequence similarities

Belongs to the betacoronaviruses E protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    85
  • Mass (Da)
    9,714
  • Last updated
    2016-05-11 v1
  • Checksum
    3D6F6CB4627438A5
MFMADAYLADTVWYVGQIIFIVAICLLVTIVLVAFLATFKLCIQLCGMCNTLVLSPSIYVFNRGRQFYEFYNDVKPPVLDVDDFL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU131570
EMBL· GenBank· DDBJ
AMK59679.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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