A0A140E064 · A0A140E064_CVHOC

Function

function

Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site40Nucleophile
Active site325Charge relay system
Active site328Charge relay system

GO annotations

AspectTerm
Cellular Componenthost cell plasma membrane
Cellular Componentplasma membrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Molecular Functionhost cell surface receptor binding
Molecular Functionsialate 4-O-acetylesterase activity
Molecular Functionsialate 9-O-acetylesterase activity
Biological Processfusion of virus membrane with host plasma membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hemagglutinin-esterase
  • EC number
  • Short names
    HE protein
  • Alternative names
    • E3 glycoprotein

Gene names

    • Name
      HE

Organism names

  • Taxonomic identifier
  • Strain
    • HCoV-OC43/UK/London/2011
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Embecovirus > Betacoronavirus 1

Accessions

  • Primary accession
    A0A140E064

Proteomes

Subcellular Location

Host cell membrane
; Single-pass type I membrane protein
Virion membrane
; Single-pass type I membrane protein
Note: In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.

Features

Showing features for transmembrane, topological domain.

TypeIDPosition(s)Description
Transmembrane391-414Helical
Topological domain413-423Intravirion

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_502331303017-423Hemagglutinin-esterase
Disulfide bond44↔65
Disulfide bond113↔162
Disulfide bond306↔311
Disulfide bond346↔370

Post-translational modification

N-glycosylated in the host RER.

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. Forms a complex with the M protein in the pre-Golgi. Associates then with S-M complex to form a ternary complex S-M-HE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-376Haemagglutinin-esterase glycoprotein core
Domain129-262Haemagglutinin-esterase glycoprotein haemagglutinin

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    47,596
  • Last updated
    2016-05-11 v1
  • Checksum
    8B1D1FDBC004FD5F
MFLLPRFILVSCIIGSLGFHNPPTNVVSHVNGDWFLFGDSRSDCNHIVNINPHNYSYMDLNPALCDSGKISSKADNSIFRSFHFTDFYNYTGEGQQIIFYEGVNFTPYHAFKCNRSGSNDIWMQNKGLFYTQVYKNMAVYRSLTFVNVPYVYNGSAQATAFCKSGSLVLNNPVYIAPQANSGIITKVEADFYLSGCDEYIVPLCIFNGKFLSNTKYYDHSQYYFNKDTGVIYGLNSTETITTGFDLNCHYLVLPSGNYLSISNELLLTVPTKAICFNKRKDFTPVQVVDSRWNNARQSDNMTAVACQPPYCYFRNSTTNYVGVYDINHGDAGFTSILSGLLYNSSCFSQQGVFRYDNISSVWPLYPYGRCPTAADINIPDLPICVYDPLPVILLGILLGVAIVIIVVLFLHFMVDNVTRLHDA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU131570
EMBL· GenBank· DDBJ
AMK59676.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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