A0A140DGM9 · A0A140DGM9_HUMAN
- ProteinNADH-ubiquinone oxidoreductase chain 4
- GeneND4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids459 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 4
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A140DGM9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-41 | Helical | ||||
Sequence: HMIWINTTTHSLIISIIPLLF | ||||||
Transmembrane | 148-167 | Helical | ||||
Sequence: YFLFYTLVGSLPLLIALIYT | ||||||
Transmembrane | 196-216 | Helical | ||||
Sequence: WLAYTMAFMVKMPLYGLHLWL | ||||||
Transmembrane | 223-244 | Helical | ||||
Sequence: APIAGSMVLAAVLLKLGGYGMM | ||||||
Transmembrane | 256-277 | Helical | ||||
Sequence: HMAYPFLVLSLWGMIMTSSICL | ||||||
Transmembrane | 284-303 | Helical | ||||
Sequence: SLIAYSSISHMALVVTAILI | ||||||
Transmembrane | 309-330 | Helical | ||||
Sequence: FTGAVILMIAHGLTSSLLFCLA | ||||||
Transmembrane | 351-369 | Helical | ||||
Sequence: LLPLMAFWWLLASLANLAL | ||||||
Transmembrane | 389-409 | Helical | ||||
Sequence: SNITLLLTGLNMLVTALYSLY |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-109 | NADH:ubiquinone oxidoreductase chain 4 N-terminal | ||||
Sequence: MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISLQISLIMT | ||||||
Domain | 112-397 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNITLLLTG |
Sequence similarities
Belongs to the complex I subunit 4 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length459
- Mass (Da)51,564
- Last updated2016-05-11 v1
- ChecksumACEE43733BD270A1