A0A140D6E3 · A0A140D6E3_9ENTR
- Protein4-hydroxybenzoate octaprenyltransferase
- GenehdbP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids290 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Catalytic activity
- 4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 4-hydroxybenzoate decaprenyltransferase activity | |
Molecular Function | 4-hydroxybenzoate nonaprenyltransferase activity | |
Molecular Function | 4-hydroxybenzoate octaprenyltransferase activity | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxybenzoate octaprenyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A140D6E3
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-40 | Helical | ||||
Sequence: KPIGALLLLWPTLWALWVAA | ||||||
Transmembrane | 46-70 | Helical | ||||
Sequence: LWILAVFVAGVWLMRAAGCVVNDYA | ||||||
Transmembrane | 99-132 | Helical | ||||
Sequence: LFAVLVLLSFLLVLTLNTMTILLSVAGLALAWVY | ||||||
Transmembrane | 152-182 | Helical | ||||
Sequence: WSIPMAFAAVSESLPLSCWLMLLANILWAVA | ||||||
Transmembrane | 213-233 | Helical | ||||
Sequence: LIIGILQACVLVLMAVIGWLN | ||||||
Transmembrane | 239-257 | Helical | ||||
Sequence: FYWSILIAGALFVYQQKLI | ||||||
Transmembrane | 269-288 | Helical | ||||
Sequence: FLNNNYVGLVLFIGLAMSYW |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length290
- Mass (Da)32,602
- Last updated2016-05-11 v1
- Checksum7BCEEDE3DB05DCED