A0A140D693 · A0A140D693_9GAMM

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site169-171NADP+ (UniProtKB | ChEBI)
Binding site235NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      mthD
    • Synonyms
      folD

Organism names

Accessions

  • Primary accession
    A0A140D693

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-124Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain127-285Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    297
  • Mass (Da)
    31,485
  • Last updated
    2016-05-11 v1
  • Checksum
    B41D2755AF1337B4
MSAVPGVKLIDGKATAARVLAEVREQVLELRQGGVQPGLAVVLVGADAASHVYVRNKVLRAEEVGIRSLEHRLHADTTQAHLLALIDRLNRDPEVNGILVQLPLPGHIDEHRVLQAISPFKDVDGFHSENVGGLAQGRDVLTPCTPSACMRLLRDACGELRGKHAVVVGRSNIVGKPMAALLLQADCTVTVVHSHSRDLPALCRQADILVAAVGQPRLIGADWLKPGAVVIDVGINRVDDGGHSRLVGDVDFAAALPQVAGITPVPGGVGPMTIAYLMKNTLLALDLQQQAAHQERT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU505133
EMBL· GenBank· DDBJ
AMK07367.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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