A0A139WK58 · A0A139WK58_TRICA
- ProteinSphingomyelin phosphodiesterase
- GeneAUGUSTUS-3.0.2_32906
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids600 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts sphingomyelin to ceramide.
Catalytic activity
- a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 187 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 189 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 258 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 258 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 297 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 405 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 439 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 441 | Zn2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | lysosome | |
Molecular Function | acid sphingomyelin phosphodiesterase activity | |
Molecular Function | hydrolase activity, acting on glycosyl bonds | |
Molecular Function | metal ion binding | |
Biological Process | ceramide biosynthetic process | |
Biological Process | sphingomyelin catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSphingomyelin phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium
Accessions
- Primary accessionA0A139WK58
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5007300105 | 22-600 | Sphingomyelin phosphodiesterase | ||
Disulfide bond | 103↔114 | ||||
Disulfide bond | 202↔207 | ||||
Disulfide bond | 566↔570 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 68-154 | Saposin B-type | |||
Sequence similarities
Belongs to the acid sphingomyelinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length600
- Mass (Da)68,399
- Last updated2016-05-11 v1
- MD5 Checksum91C968AC0402FB41555D586FADE2EF98
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ971338 EMBL· GenBank· DDBJ | KYB28197.1 EMBL· GenBank· DDBJ | Genomic DNA |