A0A139WJI0 · A0A139WJI0_TRICA

Function

function

Converts sphingomyelin to ceramide.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site190Zn2+ 1 (UniProtKB | ChEBI)
Binding site192Zn2+ 1 (UniProtKB | ChEBI)
Binding site261Zn2+ 2 (UniProtKB | ChEBI)
Binding site261Zn2+ 1 (UniProtKB | ChEBI)
Binding site300Zn2+ 2 (UniProtKB | ChEBI)
Binding site408Zn2+ 2 (UniProtKB | ChEBI)
Binding site442Zn2+ 2 (UniProtKB | ChEBI)
Binding site444Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentlysosome
Molecular Functionacid sphingomyelin phosphodiesterase activity
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionmetal ion binding
Biological Processceramide biosynthetic process
Biological Processsphingomyelin catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin phosphodiesterase
  • EC number

Gene names

    • Name
      AUGUSTUS-3.0.2_32905
    • ORF names
      TcasGA2_TC032905

Organism names

  • Taxonomic identifier
  • Strain
    • Georgia GA2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium

Accessions

  • Primary accession
    A0A139WJI0

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_500730003519-602Sphingomyelin phosphodiesterase
Disulfide bond106↔117
Disulfide bond205↔210
Disulfide bond368↔416
Disulfide bond568↔572

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain71-157Saposin B-type

Sequence similarities

Belongs to the acid sphingomyelinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    602
  • Mass (Da)
    68,827
  • Last updated
    2016-05-11 v1
  • MD5 Checksum
    BFBFEF499B0029F017969D8B3FA4524D
MALLSLIYLLVFVSFTSPIDIETPEGLELVAEGLNEFFTTGREPDYLRETLQNNQLRNIFRDNVVENEDVNSKTCFFCHVIVNLLIEQRRLNASRELLATEGGYLCVNLAVENERVCKGAIERHIDILLYIVDNTPDLDSTRVCGSVLQSIGCSSGNNFNWSIQLPSGGSPFTPKSYDKKQSFKILHLSDFHFDPDYTPGGNEDCGEPICCQSDQGKPNSSETTCGYWSSYKEADTSWKLVKETVKQINTHQFDYLYYTGDIISHRVWETSIERNTKSLSQIYSYMKKKFNVPVFPVLGNHEPNPLDQWPPLDVQDEIISNRWLFELVAKLWSPLVGEDISETVLKGGYYTVSPKAGFRIIAINSNPCYSYNWWLVLNDVDPYGQLQWLADTLLEAEKNDERVHILSHVPSGTSECLSVWAREYSKIVERFANTIAGQFVGHTHQDEFYVYYNCSDDTQAVGAAFNGAAVTPWIESNPSYKIFDVDSKSFNLLDYEEWTFNLTLANSQPSAPLEWYKLYRFTEAYEVDNLSPTEVNKLLYKMAENHALLDDYYKYRYRNGDPGVEKGCDDSCKKKSLCKIATTITGDDTQCRRFTELYDRGQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ971338
EMBL· GenBank· DDBJ
KYB28198.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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