A0A139WGC4 · A0A139WGC4_TRICA

Function

Catalytic activity

  • Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
    EC:3.1.11.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

132850100150200250300
Type
IDPosition(s)Description
Binding site81Mg2+ 1 (UniProtKB | ChEBI)
Binding site109Mg2+ 1 (UniProtKB | ChEBI)
Active site182
Active site221Proton donor/acceptor
Binding site221Mg2+ 1 (UniProtKB | ChEBI)
Binding site223Mg2+ 1 (UniProtKB | ChEBI)
Site223Transition state stabilizer
Site293Important for catalytic activity
Binding site318Mg2+ 1 (UniProtKB | ChEBI)
Active site319Proton acceptor
Binding site319Mg2+ 1 (UniProtKB | ChEBI)
Site319Interaction with DNA substrate

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    exodeoxyribonuclease III
  • EC number

Gene names

    • Name
      AUGUSTUS-3.0.2_33509
    • ORF names
      TcasGA2_TC033509

Organism names

  • Taxonomic identifier
  • Strain
    • Georgia GA2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium

Accessions

  • Primary accession
    A0A139WGC4

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-35Disordered
Compositional bias12-34Basic and acidic residues
Domain79-319Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    328
  • Mass (Da)
    37,471
  • Last updated
    2016-05-11 v1
  • MD5 Checksum
    2FFEFF30E9CFFAC8E653AA511CE8B735
MLKFSVGKTAKKADSGNKEETQVEEAKKPQTRTGLATKREFVQSTKGPKNSTVTNWENINFKCTTKSPKGKAPNFHITTWNVDGLRSWLKKGCLDILKYDKPDILCIQETKCAVYKLPEEVKTIEGYETLWCCSDKDGYAGVGIMVKDKPLNVIYGIDSKEHDTEGRCITVEYETFFVVNVYVPHAGRNLVTLPKRLDWNEQFEKFIKNLDSQKPVIICGDMNVAHKEIDLANPKTNTNSAGFSVEERDGMTAFLGNGYVDIYRHLYPEKEKAYTFWIYMRNARPNNVGWRLDYFLVSQRFVDNVCDNIIHSDVMGSDHCPLSLHIQI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-34Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ971350
EMBL· GenBank· DDBJ
KYB26857.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help