A0A139WGC4 · A0A139WGC4_TRICA
- Proteinexodeoxyribonuclease III
- GeneAUGUSTUS-3.0.2_33509
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids328 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 81 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 109 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 182 | ||||
Active site | 221 | Proton donor/acceptor | |||
Binding site | 221 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 223 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 223 | Transition state stabilizer | |||
Site | 293 | Important for catalytic activity | |||
Binding site | 318 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 319 | Proton acceptor | |||
Binding site | 319 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 319 | Interaction with DNA substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | base-excision repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameexodeoxyribonuclease III
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium
Accessions
- Primary accessionA0A139WGC4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-35 | Disordered | |||
Compositional bias | 12-34 | Basic and acidic residues | |||
Domain | 79-319 | Endonuclease/exonuclease/phosphatase | |||
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length328
- Mass (Da)37,471
- Last updated2016-05-11 v1
- MD5 Checksum2FFEFF30E9CFFAC8E653AA511CE8B735
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 12-34 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ971350 EMBL· GenBank· DDBJ | KYB26857.1 EMBL· GenBank· DDBJ | Genomic DNA |