A0A139NEK3 · A0A139NEK3_9STRE

  • Protein
    DNA-directed RNA polymerase subunit beta'
  • Gene
    rpoC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site60Zn2+ 1 (UniProtKB | ChEBI)
Binding site62Zn2+ 1 (UniProtKB | ChEBI)
Binding site75Zn2+ 1 (UniProtKB | ChEBI)
Binding site78Zn2+ 1 (UniProtKB | ChEBI)
Binding site450Mg2+ (UniProtKB | ChEBI)
Binding site452Mg2+ (UniProtKB | ChEBI)
Binding site454Mg2+ (UniProtKB | ChEBI)
Binding site818Zn2+ 2 (UniProtKB | ChEBI)
Binding site892Zn2+ 2 (UniProtKB | ChEBI)
Binding site899Zn2+ 2 (UniProtKB | ChEBI)
Binding site902Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionmagnesium ion binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit beta'
  • EC number
  • Short names
    RNAP subunit beta'
  • Alternative names
    • RNA polymerase subunit beta'
    • Transcriptase subunit beta'

Gene names

    • Name
      rpoC
    • ORF names
      STRDD10_00929

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DD10
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Accessions

  • Primary accession
    A0A139NEK3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain225-504RNA polymerase N-terminal

Sequence similarities

Belongs to the RNA polymerase beta' chain family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,215
  • Mass (Da)
    135,735
  • Last updated
    2016-05-11 v1
  • Checksum
    CE851A7E74AF4A4C
MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRAKVRRERLGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEHKSIMTEREYRERLREYGPGSFVAKMGAEAIQDLLKQVDLESEIVELKEELKTATGQKRIKAVRRLDVLDAFYKSGNKPEWMILNILPVIPPDLRPMVQLDGGRFAASDLNELYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDIVQNVKAAKRLVDRGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQAEARILMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEEAGREGEGMVFKDADEAVMAYRNGYVHLHSRVGIATDSLQKPWTENQQHKVLMTTVGKILFNAIMPEDLPYLQEPNNANLTEGVPDKYFLEPGSDIKEAISKLELNVPFKKKNLGNIIAEIFKRFRTTETSALLDRLKDLGYYHSTLAGLTVGIADIPVIDNKAEIIEESHSRVEQITKQFRRGMITDEERYNAVTGEWRTAKEKLEARLLESQDPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLLIRSIADGKEMIESLEERLNGRYTKKSVKHPETGEVIVGPDTLITEDLAREIVNAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRVQEIFEARNPKGEAVITEVKGEVTAIEEDASTRTKKVYVRGTTGEGEYVVPFTARMKVEVGDQIARGAALTEGSIQPKHLLAVRDVLSVETYLLAEVQKVYRSQGVEIGDKHIEVMVRQMIRKVRVMDPGDTDLLMGTLMDVNDFTDANRDVLIAGGVPATARPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNLEPKSINEVTTLEELEAEFAAEELAEETVEK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LQRE01000077
EMBL· GenBank· DDBJ
KXT74470.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp