A0A136Q2D6 · A0A136Q2D6_9FIRM

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Active site70Proton acceptor
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site71substrate
Binding site151-154substrate
Binding site174substrate
Binding site179-180substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      HMPREF3293_02066

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 22607
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Christensenellales > Christensenellaceae > Christensenella

Accessions

  • Primary accession
    A0A136Q2D6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    21,526
  • Last updated
    2016-06-08 v1
  • Checksum
    2E2D90F3975A25A9
MKQLIIATNNQGKVREIKAILGNFYDEIKSLKDAGIVADVVEDGDSFHANARKKAVEISEMVEGDVLADDSGLCVEALDMAPGIYSARFSGEGATDEKNNVKLLSLVKDQDNRRAWFVCALVLANGGKEKLYVEERAEGKIIDEPRGENGFGYDPLFYVEEYGQTFAEIPPEVKNKISHRAKALKKLQEKVQEM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LSZW01000063
EMBL· GenBank· DDBJ
KXK64825.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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