A0A136IN16 · A0A136IN16_9PEZI

  • Protein
    tRNA (guanine-N(7)-)-methyltransferase
  • Gene
    TRM8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.

Catalytic activity

Pathway

tRNA modification; N7-methylguanine-tRNA biosynthesis.

Features

Showing features for binding site, active site.

118642004006008001,0001,2001,4001,6001,800
TypeIDPosition(s)Description
Binding site103S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site126-127S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site161-162S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site181S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site184
Binding site259-261S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functionphosphatidylinositol binding
Molecular FunctiontRNA (guanine(46)-N7)-methyltransferase activity
Molecular FunctiontRNA binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA (guanine-N(7)-)-methyltransferase
  • EC number
  • Alternative names
    • Transfer RNA methyltransferase 8
    • tRNA (guanine(46)-N(7))-methyltransferase
    • tRNA(m7G46)-methyltransferase

Gene names

    • Name
      TRM8
    • ORF names
      Micbo1qcDRAFT_153209

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • J235TASD1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Microdochiaceae > Microdochium

Accessions

  • Primary accession
    A0A136IN16

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane307-325Helical
Transmembrane331-352Helical

Keywords

Interaction

Subunit

Forms a complex with TRM82.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

TypeIDPosition(s)Description
Region1-45Disordered
Region66-91Disordered
Compositional bias70-90Polar residues
Domain401-590PXA
Region691-710Disordered
Domain717-856RGS
Compositional bias872-898Polar residues
Region872-901Disordered
Compositional bias913-927Polar residues
Region913-959Disordered
Compositional bias930-959Basic and acidic residues
Region1018-1046Disordered
Coiled coil1144-1171
Domain1180-1298PX
Domain1560-1621RRM
Region1623-1657Disordered
Domain1645-1712RRM
Region1713-1864Disordered
Compositional bias1762-1788Basic and acidic residues

Sequence similarities

Belongs to the sorting nexin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,864
  • Mass (Da)
    210,832
  • Last updated
    2016-05-11 v1
  • Checksum
    A8E35F50D59EF86B
MAGPPNKKQKREAYRQAQRESGATTMPQKKFYRQRAHANPFSDHQLEYPISPQHMDWSPYFPAFVAKPDEGNTTETSRNDPTSLPRDPKNQTLTKDVDIVDIGCGFGGLIVALSPALPDNLMIGMEIRTQVTEFVQDRIRALRSQDTEGQLYQNIGCLRANTMKFFPNFFKKAQVSKIFICFPDPHFKHRKHKARIVSTTLNSEYAYALRPGGIVYTITDVEDLHDWMVQHLSAHASFERVSEEDQEADQCVAIMKTATEEGKKVERNKGQKFVALFRRREDPPCSRTIHQHQAAHEMNMALKRRDFVIAGIVCFIAWGYAVSWFPSIRWAGYAFASGLTTALIGVLAALVLTSQGSSYSRRHRSARPDAVAFVAPKSWSLETTALRARQAYVRQPLLPESPSLSRALDELLGLILRDFVDSWYSRISKNPVFTNEVDRNIRFALSALRDRLAEADLVEAAISRIVPILTDHFRDFFDAERAVRGRKLNRDVTESEELDLAIAAKFRDGKLHAAASLSYADTKIVRQEHLRKMVTRILPQVLPENMITSRAVLSIVREIVSCAVLFPVMQVLSEPDTWNQIMENYGRSMLQDRSTVRKLRAALDAHASPAPKTPKMAAFPRIAPGDGERTFERFMRTIRKLNNLSDARRFRSEVASQLKRDSQVEGQDQAYLRRLEMGKKLLDQKVQHLAAGGDRHGTNPTQLSAPSLESSKLERASLAELLRDTSGLSYFMEFMDRQGMMTHVQFWLVVDGFRNPLEDDGPEDAELPSTTVPWTDSDRTDLAQIDQAYLTKPELRVPVSSRQAIREFLAAGKAATNKQYYAARRSVLRAQSTVLEEMETRYLQAFKKSDLFFKALAAEEAARNATQQSHMAAPELHRASQSFTTKPTVGSTKANPRLKAVQPQFKRVLSAAELGQANSSSSSMDPLHGPRRSLDADARTHVRQNSEDSSHTPLFDDDDLEHDALGESVQSLEQDTAKVGPDTQVVQAMEQALNNIMENERPQTAEEIRESLFGEDDAQPSLFSGLEQDNASLENSRVLPDGKEGDRPSITSLGLVSQASRIGVFVDNDLFGDEEKFLSDELEEVGEEPKGNIEDEVHEAAPGDLGLAEAITALTNDIDKLVAQEAVLESLTRKAELTNNTAELRILRKSRASLQRELRRKELQRQQYVIQESDNSLYGKASVQIKSIQVGKDEDGKEFAVYVVEVQRRAGEQMPAATWIVTRRYSEFHDLHQRLRLRYPSVRHLDFPRRRMVMKLQSDFLRKRSQALEQYLKELLQLPDVCRSRDLRSFLSQSVITQGEDILNREDKKDMMSRLYDSVADGMEDILGNIPVLDQLSVAGQNLIAAATNQMNTIPLNATEGAITAAEAEAELNAFEDKELEPFIKPICDIFLEIFGLNRGNNWLRGRAVVVVLHQLLGGTIERKVRDIYKVLIQEEALVRYLRLVTDSMWPGGQMKRDRQPRTASEKAKTRREASLMLATLVPDVAGSVVGRLNAQAASRRIFATLNNQRLTTHLVFTIADEIIDVLFPEQLDAVIPVPWHPPRFRPPGSTWAISQRAVTTKTDLETHFATHGTGEITEIKLMNGFGFVEYKDPMDARDVVPAFHGSDFMGQRLTVQFARGSRQREAGFGGNNERQPPRPRRTPHRMQITGLPNDTSWQDLKDFARQSSLDVVFSETGRDGNGRGFVEFESAADLRTAIEKLDQREFKGQRVTCIADTQPDMPFRDRGRSRSPGFRKPYGMPRDPYDRRGPPPTGYSPPRGGYREDYRDRSPRREYYDDRRYRSPPRRGPPMEEYGAPPRRYDDPYRRDYGPPPADPYAAGRGYDRPPREFPPREPGYPPRDPGGYPPHPREDYRRGNGGPPGY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias70-90Polar residues
Compositional bias872-898Polar residues
Compositional bias913-927Polar residues
Compositional bias930-959Basic and acidic residues
Compositional bias1762-1788Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ964269
EMBL· GenBank· DDBJ
KXJ86311.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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