A0A135NYS8 · A0A135NYS8_9HYPH

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site27-32GTP (UniProtKB | ChEBI)
Binding site144-147GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionguanosine tetraphosphate binding
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • ORF names
      ATO67_12470

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R89-1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Agrobacterium

Accessions

  • Primary accession
    A0A135NYS8

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-197Tr-type G

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    612
  • Mass (Da)
    67,684
  • Last updated
    2016-06-08 v1
  • Checksum
    A1239DBC98CD3097
MARGMSTNSTRTPLDHIRNFSIVAHIDHGKSTLADRLIQSTGGLAERDMSEQVLDNMDIERERGITIKAQTVRLHYKANNGEIYVLNLIDTPGHVDFAYEVSRSLSACEGSLLVVDASQGVEAQTLANVYQAIDNDHEIVTVLNKIDLPAAEPDRIREQIEEVIGIDASQAVLISAKTGLGIPDVLEAIVHQLPPPKSELGEKGPLKALLVDSWYDTYLGVMVLVRVLDGVLTKGQTIRMMGTDAKYQVERVGVLTPKMVAVDSLGPGEIGFITGSIKEVADTRVGDTITEDKRPTAKALPGFKPAQPVVFCGLFPVDAADFEDLRAAMGKLRLNDASFSFEMESSAALGFGFRCGFLGLLHLEIIQERLEREFDLDLIATAPSVVYQLTMTDGSERELHNPADMPDVVKISEIREPWIKATILTPDDYLGGILKLCQDRRGVQTELTYVGKRAMLTYELPLNEVVFDFYDRLKSISKGYASFDYHLDGYREGNLVKMSIMVNGEPVDALSMLVHRTAADKRGRDMCEKLKDLIPRHMFKIPIQAAIGGNVIARETISAMRKDVTAKCYGGDATRKRKLLDKQKEGKKRMRQFGKVDIPQEAFIAALKMSDD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LNUW01000037
EMBL· GenBank· DDBJ
KXG84330.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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