A0A133NN20 · A0A133NN20_GARVA

  • Protein
    Serine--tRNA ligase
  • Gene
    serS
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site231L-serine (UniProtKB | ChEBI)
Binding site231-233L-serine (UniProtKB | ChEBI)
Binding site262L-serine (UniProtKB | ChEBI)
Binding site262-264ATP (UniProtKB | ChEBI)
Binding site278ATP (UniProtKB | ChEBI)
Binding site278-281ATP (UniProtKB | ChEBI)
Binding site285L-serine (UniProtKB | ChEBI)
Binding site349-352ATP (UniProtKB | ChEBI)
Binding site382L-serine (UniProtKB | ChEBI)
Binding site384L-serine (UniProtKB | ChEBI)
Site384Important for serine binding

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionserine-tRNA ligase activity
Molecular FunctiontRNA binding
Biological Processselenocysteine biosynthetic process
Biological Processseryl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine--tRNA ligase
  • EC number
  • Alternative names
    • Seryl-tRNA synthetase
      (SerRS
      )
    • Seryl-tRNA(Ser/Sec) synthetase

Gene names

    • Name
      serS
    • ORF names
      HMPREF3216_01028

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GED7760B
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Bifidobacteriales > Bifidobacteriaceae > Gardnerella

Accessions

  • Primary accession
    A0A133NN20

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The tRNA molecule binds across the dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain186-408Aminoacyl-transfer RNA synthetases class-II family profile

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    47,660
  • Last updated
    2016-06-08 v1
  • Checksum
    44C54607B6689758
MLDIQFIREHADIVKESQRKRGESVELVDEVLRADDLRRTSLKAFEAARADQKAIGKKVAAAQNSEKATLIAQTKELAQKVAEFKAQSEQATADYTTAMWKLSNIVEDEAPEGGEDDYVVVKKVGTPRDFAAEGFEPKDHLTLGTGVAGIDMRRGVKVAGSRFYFLRGAVARLQIAMLTMAVDQAEEHGFTLAITPTLVRPEVMRGTGFLNSHADEIYRLREPDDQYLVGTSEVALAGMHEDEILDLSNGALRYCGWSSCYRREAGAAGKDTSGIIRVHQFDKVEMFVYCKQEDSRAEHQKLLGMEQEMLAKVEVPYRIIDTAAGDLGSSAARKFDCEAWVPTQGRYRELTSTSNCTEYQARRLNVRERMEDGGTRPVSTLNGTLATTRWLVAILENHQHEDGSIDIPKAMQAYMGGKEVIEPTKWEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LRQA01000048
EMBL· GenBank· DDBJ
KXA17667.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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