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A0A133MWK0 · A0A133MWK0_ENTFC

Function

function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site231L-serine (UniProtKB | ChEBI)
Binding site231-233L-serine (UniProtKB | ChEBI)
Binding site262L-serine (UniProtKB | ChEBI)
Binding site262-264ATP (UniProtKB | ChEBI)
Binding site285L-serine (UniProtKB | ChEBI)
Binding site349-352ATP (UniProtKB | ChEBI)
Binding site382L-serine (UniProtKB | ChEBI)
Binding site384L-serine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionserine-tRNA ligase activity
Molecular Functiontransferase activity
Biological Processselenocysteine biosynthetic process
Biological Processseryl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine--tRNA ligase
  • EC number
  • Alternative names
    • Seryl-tRNA synthetase
      (SerRS
      )
    • Seryl-tRNA(Ser/Sec) synthetase

Gene names

    • Name
      serS
    • ORF names
      CI258_011025
      , HV425_02155

Organism names

Accessions

  • Primary accession
    A0A133MWK0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The tRNA molecule binds across the dimer.

Family & Domains

Features

Showing features for coiled coil, domain.

Type
IDPosition(s)Description
Coiled coil34-103
Domain172-409Aminoacyl-transfer RNA synthetases class-II family profile

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    48,195
  • Last updated
    2016-06-08 v1
  • MD5 Checksum
    3E7066B763A7FE111519C9F8D721B4CB
MLDVKMMRQNIEEVQEKLMTRGVKKETLVEFMELDENRRKLLVKSEELKKYRNDVSAEIAQLKRAKEDASAKIAEMKEVGGNIKALDTEIAEVDEKLKQIATTLPNLPHDSVPVGSDEEDNVEIRRWSEPRTFAFEPKPHWEIAENLDILDFERGAKVAGSRFVYYKGLGARLERAVYNFMLDQHIYEHGYTEMITPYIVNSKAMFGTGQFPKFKEDVFQLENTDLTLIPTAEVPLTNYYNDEILDGADLPVYFTALSPAFRSEAGSAGRDTRGLIRLHQFNKVEMVKFSDAEHSYEELEKMTADAEDILKKLHLPYRVMALSTGDMGFSAAKTYDLEVWIPAQDTYREISSCSNCEDFQARRAMIRYRDNDGKIHYAHTLNGSGLAVGRTVAAILENYQNEDGSVTVPEALVPYMGNLKVIK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABWVJ010000001
EMBL· GenBank· DDBJ
NVD82240.1
EMBL· GenBank· DDBJ
Genomic DNA
NPOO02000010
EMBL· GenBank· DDBJ
PWF38232.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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