A0A132MLD9 · A0A132MLD9_9ACTN

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site74Na+ (UniProtKB | ChEBI); structural
Binding site77Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • ORF names
      LI90_185

Organism names

Accessions

  • Primary accession
    A0A132MLD9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane33-57Helical
Transmembrane64-82Helical
Transmembrane94-120Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    123
  • Mass (Da)
    12,438
  • Last updated
    2016-06-08 v1
  • Checksum
    493C42A1D7265B0E
MLDVLLVALGAMAGAPLRYLVDRWISARHDTVFPWGTFTVNVAGSLVLGLVTGAAAAHGLPRSVVLLAGTGFCGALTTFSTFGYETVRLVEDGAYGYAAGNVLGSAAAGLMAVTAGYALATSL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LAXD01000001
EMBL· GenBank· DDBJ
KWW98559.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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