A0A127EG64 · A0A127EG64_CLOPF

  • Protein
    Shikimate dehydrogenase (NADP(+))
  • Gene
    aroE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site14-16shikimate (UniProtKB | ChEBI)
Binding site61shikimate (UniProtKB | ChEBI)
Active site65Proton acceptor
Binding site86shikimate (UniProtKB | ChEBI)
Binding site101shikimate (UniProtKB | ChEBI)
Binding site125-129NADP+ (UniProtKB | ChEBI)
Binding site212NADP+ (UniProtKB | ChEBI)
Binding site214shikimate (UniProtKB | ChEBI)
Binding site235NADP+ (UniProtKB | ChEBI)
Binding site242shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      JFP838_03935

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JP838
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium

Accessions

  • Primary accession
    A0A127EG64

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-88Shikimate dehydrogenase substrate binding N-terminal
Domain115-212Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    30,466
  • Last updated
    2016-06-08 v1
  • Checksum
    2ED0AA18B61D7CD0
MKLFGLIGEKLGHSLSPEIHNKVFKDNNIDGLYNLFSVKKEFKNNIVESLKCLGVKGANVTIPYKENVMDQLDIISQEAKAIGAVNTILIKDGKSYGYNTDYYGFGKMLERAKVNIEGNSFFVLGAGGAARSILKYLEDSKAKKIVLVSRDKEKAFDKFKDFNINFMSYGDLEEINEEFALINTTPCGMYPNINSVAVSERVIKKFKVAVDIVYNPLETKFLKMAKDNGLKTVDGLFMLVGQGVKAEEIWNGIKVDKSTEEDIYEELKCRF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP010994
EMBL· GenBank· DDBJ
AMN34934.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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