A0A126GUR6 · A0A126GUR6_DROME
- ProteinSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- GeneScsbetaA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids452 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 79 | Important for substrate specificity | |||
Binding site | 83 | ATP (UniProtKB | ChEBI) | |||
Binding site | 90-92 | ATP (UniProtKB | ChEBI) | |||
Site | 147 | Important for substrate specificity | |||
Binding site | 243 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 258 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 309 | substrate; ligand shared with subunit alpha | |||
Binding site | 366-368 | substrate; ligand shared with subunit alpha | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | succinate-CoA ligase complex | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Biological Process | succinyl-CoA metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA0A126GUR6
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 46-275 | ATP-grasp | |||
Sequence similarities
Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length452
- Mass (Da)49,087
- Last updated2016-05-11 v1
- Checksum63F70F0A43BA1D1A
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q95U38 | Q95U38_DROME | ScsbetaA | 503 | ||
A0A0B4JCW4 | A0A0B4JCW4_DROME | ScsbetaA | 451 | ||
Q9VHJ8 | Q9VHJ8_DROME | ScsbetaA | 502 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | ALI30546.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ALI30547.1 EMBL· GenBank· DDBJ | Genomic DNA |