A0A126GUR6 · A0A126GUR6_DROME

Function

function

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for site, binding site.

Type
IDPosition(s)Description
Site79Important for substrate specificity
Binding site83ATP (UniProtKB | ChEBI)
Binding site90-92ATP (UniProtKB | ChEBI)
Site147Important for substrate specificity
Binding site243Mg2+ (UniProtKB | ChEBI)
Binding site258Mg2+ (UniProtKB | ChEBI)
Binding site309substrate; ligand shared with subunit alpha
Binding site366-368substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Biological Processsuccinyl-CoA metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
  • EC number
  • Alternative names
    • ATP-specific succinyl-CoA synthetase subunit beta
      (A-SCS
      )
    • Succinyl-CoA synthetase beta-A chain
      (SCS-betaA
      )

Gene names

    • Name
      ScsbetaA
    • Synonyms
      A-Sbeta
      , CGI 1963
      , Dmel\CG11963
      , FBgn0037643
      , SkAP
      , Skap
      , skap
    • ORF names
      CG11963
      , Dmel_CG11963

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    A0A126GUR6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

    • FBgn0037643Expressed in early elongation stage spermatid (Drosophila) in testis and 253 other cell types or tissues

Interaction

Subunit

Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain46-275ATP-grasp

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    452
  • Mass (Da)
    49,087
  • Last updated
    2016-05-11 v1
  • Checksum
    63F70F0A43BA1D1A
MASFLARTGGPLIETVRPAAIKKILGLAPIAVQQLRNLNVQEHVSYSLLNEAKIPTPRFAVAKNGKEANDIATKLKTDNLVLKAQVLAGGRGKGTFKNGLKGGVRVVYDPQTAEELSSKMIDQLLVTKQTGAAGRICKKVMVAERKFPRREFYFAVMMERAFNGPVLIASKEGGVDIEEVAASSPDAILYEPIDIGTGLTSEQAEKIVKKVGLGGDGEDTHVQMLLNLYDLFVKKDALLVEINPYAEDAMSGCFFALDAKLRFDDNAEFRQKELFALRDWTQEDPKEVEAAKYNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAEAVKAAFKIITSDPKVLCILVNIFGGIMRCDVIAEGIISATKDLNLNMPVVVRLQGTKVKEARELIRTSGLKILARDDLDKAADLAVHLAQIVKLAREMKMDVNFEIPDAQK

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q95U38Q95U38_DROMEScsbetaA503
A0A0B4JCW4A0A0B4JCW4_DROMEScsbetaA451
Q9VHJ8Q9VHJ8_DROMEScsbetaA502

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
ALI30546.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ALI30547.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp