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A0A125YSC7 · FNT1_TOXGM

Function

function

Monocarboxylate-proton symporter; active in acidic-to-neutral pH range (PubMed:30237165).
Transports L-lactate and formate (PubMed:30237165, PubMed:33762657).
Probably acts as a primary L-lactate transporter in extracellular tachyzoites (PubMed:33762657).

Miscellaneous

Not sensitive to p-chloromercuribenzene sulfonate (pCMBS) (PubMed:30237165).
Inhibitors modestly slow the asexual reproduction of parasites (PubMed:30237165).
Frameshift mutations that are likely to render the resulting proteins non-functional, have no significant effects on tachyzoite proliferation in vitro (PubMed:33762657).

Catalytic activity

Activity regulation

Inhibited by methyl methanethiosulfonate (MMTS) (PubMed:30237165).
Partially inhibited by the Malaria Box compound MMV007839 (PubMed:30237165).
Partially inhibited by BH-296, BH-317, BH-326 and BH-388 compounds (PubMed:30237165).

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionhigh-affinity secondary active nitrite transmembrane transporter activity
Biological Processnitrite transport

Names & Taxonomy

Protein names

  • Recommended name
    Formate-nitrite transporter 1
  • Short names
    TgFNT1

Gene names

    • ORF names
      TGME49_209800

Organism names

Accessions

  • Primary accession
    A0A125YSC7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-32Cytoplasmic
Transmembrane33-53Helical
Topological domain54-69Extracellular
Transmembrane70-90Helical
Topological domain91-116Cytoplasmic
Transmembrane117-137Helical
Topological domain138-164Extracellular
Transmembrane165-185Helical
Topological domain186-192Cytoplasmic
Transmembrane193-213Helical
Topological domain214-237Extracellular
Transmembrane238-258Helical
Topological domain259-412Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis93Reduces lactate transport. Reduces sensitivity to MMV007839 inhibition.

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004613241-412Formate-nitrite transporter 1
Glycosylation151N-linked (GlcNAc...) asparagine

Keywords

Interaction

Subunit

Homopentamer.

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    412
  • Mass (Da)
    44,290
  • Last updated
    2016-04-13 v1
  • MD5 Checksum
    96F9A3DB1A8F4043073001F6D31DD14C
MVVTASPDTYLHVIDYGLKKVRLRFDRLLLQAFMAGVYIGMAGNACISLAGGFSTDPADPKAITAGVQKFIYASIFPVAFIAIIMTGAELFTGNTMTMLICWFERRITIWQLLQNWAGSFLGNWLGTMFSAYFLTYLCCPFDHDPYLSYLNYTAASKVSYGWGSCFLRGVGCNTWVCLAVWFVVACDDAAGKILALWFPIVAFVLSSYEHIIANLYTLQLCAMLGVDTSLADMIAFNLLPTLLGNLFGGCGLIGMVYFYNFYPVVGHGDDAAEGSICGSSEKEECPSLVGVPRGASVNSLAVSAIPSVFSAPRGQRESFAGESSTLVMGDIKRQRSMASTRKLGGGADKKDVQLTVRQFDETEMQSTMEDMFGLEDPRNAPKGNPGTNPPSKSPESSATGGTGAAASPTATS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE138815
EMBL· GenBank· DDBJ
EPT32283.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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