A0A125RAL2 · A0A125RAL2_9EURY
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids417 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter
Accessions
- Primary accessionA0A125RAL2
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-284 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: EKILSAKAGHEVTPGEIIEIPVDLAMSHDGTSPPAIKTFEKVSDKVWDPEKIAIIFDHNIPANTIGSAEFQKVCRDFIKTQNITKNFIHGEGICHQVVPEMGLVEPGMVVVGADSHTCTYGAFGAFSTGMGATDLAMVWATGKTWFMVPEAIRMEVEGELNSYIAPKDIILNIIGEIGIAGATYKTAEFCGETIENMGVEGRATMCNMAIEMGAKNGIMEPNREVIDYICQRTGKNESELNIVKSDDDATYAQEMHFDINDMEPQIACPNDVDNVKAISK | ||||||
Domain | 282-409 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: ISKIEGTSIDQCLIGSCTNGRLSDLKEAAEILEGEKINDSIRLIILPASREIYKQAMHLGYIDTFIDAGAIICNPGCGPCLGGHMGVLSEGESCISTTNRNFKGRMGDPASSVYLANSKVVAASAITG |
Sequence similarities
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length417
- Mass (Da)44,907
- Last updated2016-04-13 v1
- Checksum5C5725267FFE7938
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP010834 EMBL· GenBank· DDBJ | AMD16752.1 EMBL· GenBank· DDBJ | Genomic DNA |