A0A125QVC0 · A0A125QVC0_9BILA
- ProteinCytochrome c oxidase subunit 1
- Genecox1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids441 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Heterakoidea > Heterakidae > Heterakis
Accessions
- Primary accessionA0A125QVC0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 7-29 | Helical | |||
Transmembrane | 49-71 | Helical | |||
Transmembrane | 92-110 | Helical | |||
Transmembrane | 130-153 | Helical | |||
Transmembrane | 174-201 | Helical | |||
Transmembrane | 221-246 | Helical | |||
Transmembrane | 258-282 | Helical | |||
Transmembrane | 294-316 | Helical | |||
Transmembrane | 328-348 | Helical | |||
Transmembrane | 368-390 | Helical | |||
Transmembrane | 402-422 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length441
- Mass (Da)48,735
- Last updated2016-04-13 v1
- Checksum10F5CE68BE49CF6B
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 441 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP308308 EMBL· GenBank· DDBJ | AKR75410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308309 EMBL· GenBank· DDBJ | AKR75411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308310 EMBL· GenBank· DDBJ | AKR75412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308311 EMBL· GenBank· DDBJ | AKR75413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308312 EMBL· GenBank· DDBJ | AKR75414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308313 EMBL· GenBank· DDBJ | AKR75415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308314 EMBL· GenBank· DDBJ | AKR75416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308315 EMBL· GenBank· DDBJ | AKR75417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308316 EMBL· GenBank· DDBJ | AKR75418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308317 EMBL· GenBank· DDBJ | AKR75419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308318 EMBL· GenBank· DDBJ | AKR75420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308319 EMBL· GenBank· DDBJ | AKR75421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308320 EMBL· GenBank· DDBJ | AKR75422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308321 EMBL· GenBank· DDBJ | AKR75423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308322 EMBL· GenBank· DDBJ | AKR75424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308323 EMBL· GenBank· DDBJ | AKR75425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308324 EMBL· GenBank· DDBJ | AKR75426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308325 EMBL· GenBank· DDBJ | AKR75427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308326 EMBL· GenBank· DDBJ | AKR75428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308327 EMBL· GenBank· DDBJ | AKR75429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308328 EMBL· GenBank· DDBJ | AKR75430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308329 EMBL· GenBank· DDBJ | AKR75431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308330 EMBL· GenBank· DDBJ | AKR75432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308331 EMBL· GenBank· DDBJ | AKR75433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308332 EMBL· GenBank· DDBJ | AKR75434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308333 EMBL· GenBank· DDBJ | AKR75435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308334 EMBL· GenBank· DDBJ | AKR75436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308335 EMBL· GenBank· DDBJ | AKR75437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308336 EMBL· GenBank· DDBJ | AKR75438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308337 EMBL· GenBank· DDBJ | AKR75439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308338 EMBL· GenBank· DDBJ | AKR75440.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308339 EMBL· GenBank· DDBJ | AKR75441.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308340 EMBL· GenBank· DDBJ | AKR75442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308341 EMBL· GenBank· DDBJ | AKR75443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308342 EMBL· GenBank· DDBJ | AKR75444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308343 EMBL· GenBank· DDBJ | AKR75445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308344 EMBL· GenBank· DDBJ | AKR75446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308345 EMBL· GenBank· DDBJ | AKR75447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308346 EMBL· GenBank· DDBJ | AKR75448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308347 EMBL· GenBank· DDBJ | AKR75449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308348 EMBL· GenBank· DDBJ | AKR75450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308349 EMBL· GenBank· DDBJ | AKR75451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308350 EMBL· GenBank· DDBJ | AKR75452.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308351 EMBL· GenBank· DDBJ | AKR75453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308352 EMBL· GenBank· DDBJ | AKR75454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308353 EMBL· GenBank· DDBJ | AKR75455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308354 EMBL· GenBank· DDBJ | AKR75456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308355 EMBL· GenBank· DDBJ | AKR75457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308356 EMBL· GenBank· DDBJ | AKR75458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308357 EMBL· GenBank· DDBJ | AKR75459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308358 EMBL· GenBank· DDBJ | AKR75460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308359 EMBL· GenBank· DDBJ | AKR75461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308360 EMBL· GenBank· DDBJ | AKR75462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308361 EMBL· GenBank· DDBJ | AKR75463.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308362 EMBL· GenBank· DDBJ | AKR75464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP308363 EMBL· GenBank· DDBJ | AKR75465.1 EMBL· GenBank· DDBJ | Genomic DNA |