A0A125QVC0 · A0A125QVC0_9BILA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • CD1
    • CD2
    • CD3
    • CD4
    • CD5
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Ascaridomorpha > Heterakoidea > Heterakidae > Heterakis

Accessions

  • Primary accession
    A0A125QVC0

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-29Helical
Transmembrane49-71Helical
Transmembrane92-110Helical
Transmembrane130-153Helical
Transmembrane174-201Helical
Transmembrane221-246Helical
Transmembrane258-282Helical
Transmembrane294-316Helical
Transmembrane328-348Helical
Transmembrane368-390Helical
Transmembrane402-422Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-441Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    441
  • Mass (Da)
    48,735
  • Last updated
    2016-04-13 v1
  • Checksum
    10F5CE68BE49CF6B
SSNHKDIGTLYFLFGIWSGMVGSSLSLIIRLELAKPGVLLADGQLYNSIITAHAIMMIFFMVMPTMIGGFGNWMLPLLLGAPDMSFPRLNNLSFWLLPTAMVLILGSTLVDSGCGTSWTIYPPLSTSGHPGSSVDLAIFSLHCAGISSILGGINFMTTTKNLRSSSISLEHMSLFVWTVFVTVFLLILSLPVLAGAITMLLTDRNLNTSFFDPSSGGNPLIYQHLFWFFGHPEVYILILPAFGIISHSSLYLTGKKEVFGSLGMVYAILSIALIGCVVWAHHMYTVGMDLDTRAYFTAATMVIAVPTGVKVFSWLATLFGTKMVFQPLLLWVMGFIFLFTIGGLTGVMLSNSSLDIILHDTYYVVSHFHYVLSMGAVFGIFTGITLWWSYMTGFAYDKMQMSVVFLLLFVGVNLTFFPLHFAGLQGYPRKYMDYPDIYSVW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue441

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP308308
EMBL· GenBank· DDBJ
AKR75410.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308309
EMBL· GenBank· DDBJ
AKR75411.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308310
EMBL· GenBank· DDBJ
AKR75412.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308311
EMBL· GenBank· DDBJ
AKR75413.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308312
EMBL· GenBank· DDBJ
AKR75414.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308313
EMBL· GenBank· DDBJ
AKR75415.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308314
EMBL· GenBank· DDBJ
AKR75416.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308315
EMBL· GenBank· DDBJ
AKR75417.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308316
EMBL· GenBank· DDBJ
AKR75418.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308317
EMBL· GenBank· DDBJ
AKR75419.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308318
EMBL· GenBank· DDBJ
AKR75420.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308319
EMBL· GenBank· DDBJ
AKR75421.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308320
EMBL· GenBank· DDBJ
AKR75422.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308321
EMBL· GenBank· DDBJ
AKR75423.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308322
EMBL· GenBank· DDBJ
AKR75424.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308323
EMBL· GenBank· DDBJ
AKR75425.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308324
EMBL· GenBank· DDBJ
AKR75426.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308325
EMBL· GenBank· DDBJ
AKR75427.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308326
EMBL· GenBank· DDBJ
AKR75428.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308327
EMBL· GenBank· DDBJ
AKR75429.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308328
EMBL· GenBank· DDBJ
AKR75430.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308329
EMBL· GenBank· DDBJ
AKR75431.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308330
EMBL· GenBank· DDBJ
AKR75432.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308331
EMBL· GenBank· DDBJ
AKR75433.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308332
EMBL· GenBank· DDBJ
AKR75434.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308333
EMBL· GenBank· DDBJ
AKR75435.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308334
EMBL· GenBank· DDBJ
AKR75436.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308335
EMBL· GenBank· DDBJ
AKR75437.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308336
EMBL· GenBank· DDBJ
AKR75438.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308337
EMBL· GenBank· DDBJ
AKR75439.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308338
EMBL· GenBank· DDBJ
AKR75440.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308339
EMBL· GenBank· DDBJ
AKR75441.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308340
EMBL· GenBank· DDBJ
AKR75442.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308341
EMBL· GenBank· DDBJ
AKR75443.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308342
EMBL· GenBank· DDBJ
AKR75444.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308343
EMBL· GenBank· DDBJ
AKR75445.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308344
EMBL· GenBank· DDBJ
AKR75446.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308345
EMBL· GenBank· DDBJ
AKR75447.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308346
EMBL· GenBank· DDBJ
AKR75448.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308347
EMBL· GenBank· DDBJ
AKR75449.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308348
EMBL· GenBank· DDBJ
AKR75450.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308349
EMBL· GenBank· DDBJ
AKR75451.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308350
EMBL· GenBank· DDBJ
AKR75452.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308351
EMBL· GenBank· DDBJ
AKR75453.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308352
EMBL· GenBank· DDBJ
AKR75454.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308353
EMBL· GenBank· DDBJ
AKR75455.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308354
EMBL· GenBank· DDBJ
AKR75456.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308355
EMBL· GenBank· DDBJ
AKR75457.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308356
EMBL· GenBank· DDBJ
AKR75458.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308357
EMBL· GenBank· DDBJ
AKR75459.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308358
EMBL· GenBank· DDBJ
AKR75460.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308359
EMBL· GenBank· DDBJ
AKR75461.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308360
EMBL· GenBank· DDBJ
AKR75462.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308361
EMBL· GenBank· DDBJ
AKR75463.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308362
EMBL· GenBank· DDBJ
AKR75464.1
EMBL· GenBank· DDBJ
Genomic DNA
KP308363
EMBL· GenBank· DDBJ
AKR75465.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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