A0A124BXX0 · A0A124BXX0_ASPNG
- ProteinD-xylose reductase [NAD(P)H]
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids282 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.
Catalytic activity
- NAD+ + xylitol = D-xylose + H+ + NADH
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 55 | Proton donor | ||||
Sequence: Y | ||||||
Site | 80 | Lowers pKa of active site Tyr | ||||
Sequence: K | ||||||
Binding site | 113 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | oxidoreductase activity | |
Biological Process | small molecule metabolic process |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameD-xylose reductase [NAD(P)H]
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionA0A124BXX0
Proteomes
Organism-specific databases
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-265 | NADP-dependent oxidoreductase | ||||
Sequence: IPASQTEKAVLEALKVGYRHVDSAIMYRNEKACGRAIANSGLPRSEIFFTTKIPPGSMGYDRTKRAIDSSLREAQQEYFDLILLHAPYGGKEARLGSWKALVEAQKAGKTRSIGVSNYGIHHLDELEEYIKSGGGGQIDVGQYELHPWLDRSEIAEWLQKRDIVVQAYSPLAHGTRMGERVLKELGKKYGKSPAQIMIRWGLQKGFVPLPKSVTPSRIQENAEVFDFALTEEEMKLL |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length282
- Mass (Da)31,661
- Last updated2016-04-13 v1
- ChecksumC4017EDAE5C2C42C