A0A109UUT3 · A0A109UUT3_9EURY

Function

function

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-18GTP (UniProtKB | ChEBI)
Active site13Proton acceptor
Binding site13Mg2+ (UniProtKB | ChEBI)
Binding site13-16IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site40-43IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site42Mg2+ (UniProtKB | ChEBI)
Binding site42-44GTP (UniProtKB | ChEBI)
Active site43Proton donor
Binding site127IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site141IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site179IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site194IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site252-258substrate
Binding site256IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site258GTP (UniProtKB | ChEBI)
Binding site284-286GTP (UniProtKB | ChEBI)
Binding site323-325GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • Name
      purA
    • ORF names
      TL18_07145

Organism names

  • Taxonomic identifier
  • Strain
    • YE315
  • Taxonomic lineage
    Archaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter

Accessions

  • Primary accession
    A0A109UUT3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    37,016
  • Last updated
    2016-04-13 v1
  • Checksum
    5E9A10ED1CF4FE6B
MTCSILVGGAWGDEGKGKCITYLCDADKPDIIARAGVGPNAGHSVEFNGEKYGLRLTPSGFVHTGAKLMIGAGVLVNPDVLYKEFEDLKKYNVKERMCIDPRCAIINEDHLSRDKNSEYLSKKIGSTGSGCGPANSDRVMRTIEIARDIPELEEYLTDVSLACNEAIDNGEEVFIEGSQGFALSLYYGSYPFVTSKDTTASTFAADVGVGPTKIDEVINVFKSYISRVGSGPFPTEMTQEEAERQGLEEYGVVTGRRRRIGYFDMELAKESCRINGATQIALTCVDKLFDCARVQDYGELSAETKAFIEDIQTETGVPVTIISTGPDLKDTIDLRKELL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP010834
EMBL· GenBank· DDBJ
AMD17813.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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