A0A106YVZ9 · A0A106YVZ9_BURCE
- Protein4-hydroxy-tetrahydrodipicolinate synthase
- GenedapA_5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids301 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Catalytic activity
- L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 53 | Part of a proton relay during catalysis | |||
Binding site | 54 | pyruvate (UniProtKB | ChEBI) | |||
Site | 58 | L-lysine inhibitor binding; via carbonyl oxygen | |||
Site | 89 | L-lysine inhibitor binding | |||
Site | 93 | L-lysine inhibitor binding | |||
Site | 115 | L-lysine inhibitor binding | |||
Site | 116 | Part of a proton relay during catalysis | |||
Active site | 142 | Proton donor/acceptor | |||
Active site | 170 | Schiff-base intermediate with substrate | |||
Binding site | 212 | pyruvate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate synthase activity | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate synthase
- EC number
- Short namesHTPA synthase
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex
Accessions
- Primary accessionA0A106YVZ9
- Secondary accessions
Proteomes
Subcellular Location
Interaction
Structure
Sequence
- Sequence statusComplete
- Length301
- Mass (Da)31,957
- Last updated2016-04-13 v1
- Checksum39063D46FD9D7D69
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP013443 EMBL· GenBank· DDBJ | AOK17132.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LOYH01000082 EMBL· GenBank· DDBJ | KVK77716.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAEDXG010000012 EMBL· GenBank· DDBJ | MBH9697635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UARD01000044 EMBL· GenBank· DDBJ | SQA57343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SNSQ01000009 EMBL· GenBank· DDBJ | TEU50714.1 EMBL· GenBank· DDBJ | Genomic DNA |