A0A105CD75 · A0A105CD75_BURCE

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

161550100150200250300350400450500550600
TypeIDPosition(s)Description
Active site306Acyl-ester intermediate

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processdivision septum assembly
Biological ProcessFtsZ-dependent cytokinesis
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidoglycan D,D-transpeptidase FtsI
  • EC number
  • Alternative names
    • Penicillin-binding protein 3
      (PBP-3
      )

Gene names

    • Name
      ftsI
    • ORF names
      DPR02_24310
      , E3D37_39295
      , JAO13_24825

Organism names

  • Taxonomic identifier
  • Strains
    • 871
    • PT02
    • d13
    • D13
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0A105CD75

Proteomes

Subcellular Location

Membrane
; Single-pass membrane protein

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain70-218Penicillin-binding protein dimerisation
Domain259-555Penicillin-binding protein transpeptidase
Region579-598Disordered

Sequence similarities

Belongs to the transpeptidase family. FtsI subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    615
  • Mass (Da)
    66,483
  • Last updated
    2016-04-13 v1
  • MD5 Checksum
    FB7D9BF69E67242D9DBC31B563A1366C
MKPSQKRQNVKFSSSPVLGVHLPMWRSKLVVFLLFMAFVALAARAFWIQGPGNAFYQKQGESRYQRTLELPATRGKILDRNGLVLATSLPVRAIWAIPDAVPDDLDADKVNQLGKLLGMTSKELRVKLSEDKGFVYVKRQVPIDVADKVAALDIPGIYQRNEYKRFYPEGEITAHLIGFTNVEDEGQEGVELGDQKMLSGTSGVRRVIKDRLGHIVEDVAEQIPPHNGTDVDLSIDSKIQYIAYANLKAAVEKFKAKAGAAMVVDVRTGEVLALVNYPTYNPNDRSRMTGEQLRNRIMTDVFEPGSIMKPFTVSLALDLHRVTPNTLVETGNGHFVLDGAPITDDAGFGTLTVGGVIQKSSNIGATKIAMTMRPEEMWNMYTSIGLGQAPKVGFPGAVAGRLRPWKSWRRIEQATMSYGYGLSVSLFQLARAYTAIAHDGELMPVTIFKTDPNQPVVGTQVFNPTTAREVRAMLETVVAPGGTSPDAAVPGYRVGGKSGTAYKHEGHGYTRKYRASFVGMAPMPNPRIVVAVSVDEPTAGSHFGGQVSGPVFSAIAGDTMRALNVPPNMPIKQLVVSDDSPAAPSAAGPQKLAAGGGAKHMIVSSTTRNSPGVVR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEDXG010000025
EMBL· GenBank· DDBJ
MBH9699674.1
EMBL· GenBank· DDBJ
Genomic DNA
QLUZ01000015
EMBL· GenBank· DDBJ
RAQ05732.1
EMBL· GenBank· DDBJ
Genomic DNA
SNSQ01000075
EMBL· GenBank· DDBJ
TEU34338.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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