A0A104K4R4 · A0A104K4R4_9BURK
- ProteinNADH-quinone oxidoreductase subunit I
- GenenuoI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids162 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + NADH + 5 H+(in) = a quinol + NAD+ + 4 H+(out)
CHEBI:132124 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= CHEBI:24646 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
Cofactor
Note: Binds 2 [4Fe-4S] clusters per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 63 | [4Fe-4S] cluster 1 (UniProtKB | ChEBI) | |||
Binding site | 66 | [4Fe-4S] cluster 1 (UniProtKB | ChEBI) | |||
Binding site | 69 | [4Fe-4S] cluster 1 (UniProtKB | ChEBI) | |||
Binding site | 73 | [4Fe-4S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 102 | [4Fe-4S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 105 | [4Fe-4S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 108 | [4Fe-4S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 112 | [4Fe-4S] cluster 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | iron ion binding | |
Molecular Function | NADH:ubiquinone reductase (non-electrogenic) activity | |
Molecular Function | quinone binding | |
Biological Process | aerobic respiration |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase subunit I
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex
Accessions
- Primary accessionA0A104K4R4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 54-83 | 4Fe-4S ferredoxin-type | |||
Domain | 93-122 | 4Fe-4S ferredoxin-type | |||
Sequence similarities
Belongs to the complex I 23 kDa subunit family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length162
- Mass (Da)18,672
- Last updated2016-04-13 v1
- MD5 Checksum9BE0B2EEECA14FE70AFF916013B89076
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP013420 EMBL· GenBank· DDBJ | AOJ73783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP013446 EMBL· GenBank· DDBJ | AOK24027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LOTN01000027 EMBL· GenBank· DDBJ | KUZ90525.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LOXM01000264 EMBL· GenBank· DDBJ | KVG54946.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LPBJ01000092 EMBL· GenBank· DDBJ | KVP90350.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LPDO01000091 EMBL· GenBank· DDBJ | KVT51128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LPDQ01000095 EMBL· GenBank· DDBJ | KVT54642.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LPGK01000147 EMBL· GenBank· DDBJ | KVZ51471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LPHD01000187 EMBL· GenBank· DDBJ | KWA73734.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LPIX01000079 EMBL· GenBank· DDBJ | KWD98038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LPLU01000012 EMBL· GenBank· DDBJ | KWK84587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNJU01000001 EMBL· GenBank· DDBJ | KWZ61150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MTJZ01000008 EMBL· GenBank· DDBJ | OMG74077.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QTOC01000020 EMBL· GenBank· DDBJ | RQQ07926.1 EMBL· GenBank· DDBJ | Genomic DNA |