A0A103QPX8 · A0A103QPX8_9BURK

  • Protein
    Tryptophan 2,3-dioxygenase
  • Gene
    kynA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 1 heme group per subunit.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site77-81substrate
Binding site139substrate
Binding site143substrate
Binding site266Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site280substrate

GO annotations

AspectTerm
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functiontryptophan 2,3-dioxygenase activity
Biological Processtryptophan catabolic process to acetyl-CoA
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tryptophan 2,3-dioxygenase
  • EC number
  • Short names
    TDO
  • Alternative names
    • Tryptamin 2,3-dioxygenase
    • Tryptophan oxygenase
      (TO
      ; TRPO
      )
    • Tryptophan pyrrolase
    • Tryptophanase

Gene names

    • Name
      kynA
    • ORF names
      WJ33_07315

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MSMB2036
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0A103QPX8

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-36Disordered

Sequence similarities

Belongs to the tryptophan 2,3-dioxygenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    308
  • Mass (Da)
    35,244
  • Last updated
    2016-04-13 v1
  • Checksum
    940A2CD4FA2A703E
MQPPGSDAPAGCPFSGARTAAPAHEAPHVPGEAGEQAGWHDAQLDFSKSMSYGDYLSLNQILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRAALDAVHRDALPPAFKMLARVSRIFEQLVQAWNVLATMTPSEYSAMRPYLGQSSGFQSYQYRQLEFMLGNKNPQMLQPHAHRPDILDQVRATLEAPSFYDEVVRLLARRGFPIAPSRLERDWTQPTQHDDTVEAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LOXM01000276
EMBL· GenBank· DDBJ
KVG53400.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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