A0A103C737 · A0A103C737_9BURK

  • Protein
    Aspartate-semialdehyde dehydrogenase
  • Gene
    asd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site9-12NADP+ (UniProtKB | ChEBI)
Binding site72NADP+ (UniProtKB | ChEBI)
Binding site101phosphate (UniProtKB | ChEBI)
Active site134Acyl-thioester intermediate
Binding site161substrate
Binding site164-165NADP+ (UniProtKB | ChEBI)
Binding site240substrate
Binding site243phosphate (UniProtKB | ChEBI)
Binding site271substrate
Active site278Proton acceptor
Binding site354NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaspartate-semialdehyde dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionprotein dimerization activity
Biological Process'de novo' L-methionine biosynthetic process
Biological Processdiaminopimelate biosynthetic process
Biological Processisoleucine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate-semialdehyde dehydrogenase
  • EC number
  • Short names
    ASA dehydrogenase
    ; ASADH
  • Alternative names
    • Aspartate-beta-semialdehyde dehydrogenase

Gene names

    • Name
      asd
    • ORF names
      DF011_00655
      , WJ45_05240
      , WK55_14520
      , WK95_04295
      , WL73_16640

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MSMB1140WGS
    • MSMB1346WGS
    • MSMB1823
    • MSMB2167WGS
    • Bp8958
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0A103C737

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-121Semialdehyde dehydrogenase NAD-binding

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    373
  • Mass (Da)
    40,190
  • Last updated
    2016-04-13 v1
  • Checksum
    46B0026982D95610
MNVGLVGWRGMVGSVLMQRMQEEGDFDLIEPVFFSTSNTGGKAPSFAKNETTLKDATNVDELKKCDVIITCQGGDYTNDVFPKLRAAGWNGYWIDAASSLRMNDDAVIILDPVNLDVIKDALVKGTKNFIGGNCTVSLMLMALGGLFRENLVDWMTAMTYQAASGAGAQNMRELLSQMGALNGAVQEQLADPASAILDIDRRVLATMNSDAMPTSHFGVPLAGSLIPWIDKDLGNGMSKEEWKGGAETNKILGKPAMGEPGSIPVDGLCVRIGAMRCHSQALTIKLNKDVPLDEINGILASANDWVKVVPNEREASMRDLSPAKITGTLSVPVGRLRKLAMGGEYLSAFTVGDQLLWGAAEPLRRMLRILLDK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LOYM01000064
EMBL· GenBank· DDBJ
KVL09035.1
EMBL· GenBank· DDBJ
Genomic DNA
LPDQ01000060
EMBL· GenBank· DDBJ
KVT58954.1
EMBL· GenBank· DDBJ
Genomic DNA
LPFE01000009
EMBL· GenBank· DDBJ
KVW48654.1
EMBL· GenBank· DDBJ
Genomic DNA
LPIX01000063
EMBL· GenBank· DDBJ
KWE01188.1
EMBL· GenBank· DDBJ
Genomic DNA
QTOC01000001
EMBL· GenBank· DDBJ
RQQ19189.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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