A0A103B898 · A0A103B898_9BURK

  • Protein
    UDP-3-O-acyl-N-acetylglucosamine deacetylase
  • Gene
    lpxC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site78Zn2+ (UniProtKB | ChEBI)
Binding site237Zn2+ (UniProtKB | ChEBI)
Binding site241Zn2+ (UniProtKB | ChEBI)
Active site264Proton donor

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Molecular FunctionUDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-3-O-acyl-N-acetylglucosamine deacetylase
  • EC number
  • Short names
    UDP-3-O-acyl-GlcNAc deacetylase
  • Alternative names
    • UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase

Gene names

    • Name
      lpxC
    • ORF names
      BW685_07065
      , WJ33_08665
      , WJ96_31185
      , WK57_02730
      , WK67_06065

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MSMB1808WGS
    • MSMB2036
    • MSMB1157
    • MSMB1189WGS
    • A21
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0A103B898

Proteomes

Family & Domains

Sequence similarities

Belongs to the LpxC family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    33,417
  • Last updated
    2016-04-13 v1
  • Checksum
    414383FD4B882E65
MLKQRTIKSIVKTVGIGVHSGRKIELTLRPAAPGTGIVFSRVDLPTPVDIPASATSIGDTRLASVLQKDGVRVSTVEHLMSACAGLGIDNLYVDVTAEEIPIMDGSAATFVFLIQSAGIEEQNAPKRFIKVKKTVEIRDGDKFARLDPYFGFKLKFSIDFRHPAVDKTGQELEVDFANTSYVRDIARARTFGFAHEAEMLREIGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKMLDAIGDLYVIGHPLLASYTAYKSGHGLNNALLRELLANEDAYEIVTFDDPQSAPSGFGFDAQTAFA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP013446
EMBL· GenBank· DDBJ
AOK22346.1
EMBL· GenBank· DDBJ
Genomic DNA
LOXM01000283
EMBL· GenBank· DDBJ
KVG52750.1
EMBL· GenBank· DDBJ
Genomic DNA
LPBJ01000021
EMBL· GenBank· DDBJ
KVQ01489.1
EMBL· GenBank· DDBJ
Genomic DNA
LNJU01000001
EMBL· GenBank· DDBJ
KWZ59593.1
EMBL· GenBank· DDBJ
Genomic DNA
MTJZ01000007
EMBL· GenBank· DDBJ
OMG74257.1
EMBL· GenBank· DDBJ
Genomic DNA

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Disclaimer

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