A0A0Z0YZM2 · A0A0Z0YZM2_STAAU

Function

function

Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site217Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site279Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
Biological Processheme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heme A synthase
  • EC number
  • Short names
    HAS
  • Alternative names
    • Cytochrome aa3-controlling protein

Gene names

    • Name
      ctaA
    • ORF names
      NCTC7878_02053
      , SAMEA1531725_01640
      , SAMEA70245418_02081

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • EOE173
    • NCTC7878
    • MOS222
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A0Z0YZM2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-31Helical
Transmembrane64-85Helical
Transmembrane97-118Helical
Transmembrane124-147Helical
Transmembrane167-185Helical
Transmembrane215-235Helical
Transmembrane247-267Helical
Transmembrane273-298Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts with CtaB.

Family & Domains

Sequence similarities

Belongs to the COX15/CtaA family. Type 1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    306
  • Mass (Da)
    34,464
  • Last updated
    2016-04-13 v1
  • Checksum
    62F9314757C2BE46
MYKLFGKKNLKWLGVVATLMMTFVQLGGALVTKTGSADGCGSSWPLCHGALIPEFFPIDTIIELSHRAVSALSLLMVLWLVITAWKHIGYIKEIKPLSIISVGFLLLQALIGAAAVIWQQNDYVLALHFGISLISFSSVFLITLIIFSIDQKYEADELYIKKPLRRLTWLMAIIIYCGVYTGALVRHADASLAYGGWPLPFHDLVPHSEQDWVQLTHRIMAFIVFTIIMITYIHAVKNYPNNRTVHYGYTAAFILVILQVITGALSIMTNVNLIIALFHALFITYLFGMTTYFIMLMLRSVRSDKQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAIIKR010000005
EMBL· GenBank· DDBJ
CAC8526904.1
EMBL· GenBank· DDBJ
Genomic DNA
UAUX01000008
EMBL· GenBank· DDBJ
SPZ98654.1
EMBL· GenBank· DDBJ
Genomic DNA
UELG01000009
EMBL· GenBank· DDBJ
SRZ66239.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp