A0A0Y9Z6G5 · A0A0Y9Z6G5_STAAU

  • Protein
    Methylated-DNA--protein-cysteine methyltransferase
  • Gene
    ogt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Miscellaneous

This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site130Nucleophile; methyl group acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
Biological ProcessDNA alkylation repair
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylated-DNA--protein-cysteine methyltransferase
  • EC number
  • Alternative names
    • 6-O-methylguanine-DNA methyltransferase
      (MGMT
      )
    • O-6-methylguanine-DNA-alkyltransferase

Gene names

    • Name
      ogt
    • ORF names
      NCTC7878_03085
      , SAMEA1531725_00457

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • EOE173
    • NCTC7878
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A0Y9Z6G5

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-70Methylguanine DNA methyltransferase ribonuclease-like
Domain75-158Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding

Sequence similarities

Belongs to the MGMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    173
  • Mass (Da)
    18,947
  • Last updated
    2016-04-13 v1
  • Checksum
    70949676D591B520
MVYKSYYDSPVGRLELVSDGVSLTAVLFENQQDDGTREENTSLAIFKEATQWLDAYFKGDNPEITIPLKPTGSHFQQCVWNELRQIPYGTLTTYGAIAKKVGKLLDKPKMSAQAVGGAVGSNPLSIIVPCHRVVGKTGSLTGFGGTINNKIKLLELENIDMSKLYVPKHSTKP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UAUX01000013
EMBL· GenBank· DDBJ
SPZ99935.1
EMBL· GenBank· DDBJ
Genomic DNA
UELG01000002
EMBL· GenBank· DDBJ
SRZ64443.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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