A0A0X9ZZA9 · A0A0X9ZZA9_9ALPH

Function

function

In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentanchoring junction
Cellular Componenthost cell endosome membrane
Cellular Componenthost cell Golgi membrane
Cellular Componenthost cell junction
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane

Names & Taxonomy

Protein names

  • Recommended name
    Envelope glycoprotein E

Organism names

  • Taxonomic identifier
  • Strain
    • 1532-99
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Varicellovirus > Varicellovirus equidalpha4

Accessions

  • Primary accession
    A0A0X9ZZA9

Subcellular Location

Host Golgi apparatus membrane
; Single-pass membrane protein
Host cell junction
Host cell membrane
; Single-pass type I membrane protein
Host endosome membrane
; Single-pass membrane protein
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane403-430Helical

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain197-370Envelope glycoprotein E Fc-binding
Region469-503Disordered
Region516-538Disordered

Sequence similarities

Belongs to the alphaherpesvirinae glycoprotein E family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    548
  • Mass (Da)
    61,253
  • Last updated
    2016-04-13 v1
  • Checksum
    CEC823CC63CC55EC
MELLDSRRAFFFFVLITVLDAWGVQRVELTEGAWAMIDGRDVLTPTNTTTRVTKAWTFLETPPGCAGDITVKTVCVSASLCEDNIIIGNHCNLLTGEHGIALAEFNVVNGSLQRTKDVYFVNGTVFPILAETRSVLQIQRATPSIAGVYTLHVSMNGQIKHSVVLLTVKKPPTLPRVHVKTPPPILVPQVTPEAHTDFIVRGYHSRVYAVGESFDLSVHLESHIQESSFNAEIQWYYMNTSSSSCDLFRVFETCIFHPTAMACLHPEQHACCFTSPVRATKILHRVYGNCSNRGSTWPSRCHSTLLGDRPHFIQPAPNRVDLLFKDIPESATGLYVFVLLYNGHPEAWTYTLLSTANHFMNVLTDRTRPRPGEHFYTDHGHQLFTPHPSEATTQELGAWTRHYLAFLLIIICTCAALLIALVVWGCILYIRSNRKPYEVLNPFETVYTSVPSNDPTDEVLVFERLASDSDDSFDSSSDEELELPQPPPAAQLQPYSSLESADASRGRSGFKVWFRDTPEASPEPLHRPTPPVGPDYSKVASKLRSILK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT324744
EMBL· GenBank· DDBJ
AMB16669.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp