A0A0X8E270 · A0A0X8E270_9MICO

  • Protein
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • Gene
    dut
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site62-64substrate
Binding site75substrate
Binding site79-81substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      AWU67_04885

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ERGS5:02
  • Taxonomic lineage
    Bacteria > Bacillati > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Microterricola

Accessions

  • Primary accession
    A0A0X8E270

Proteomes

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain14-142dUTPase-like
Region133-157Disordered

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    157
  • Mass (Da)
    15,593
  • Last updated
    2016-04-13 v1
  • MD5 Checksum
    1D3D5661088B2B8DF11C9A9FEEFE0940
MAESVEVLITASVLPHYAHPGDAGADLHSAESVTLAPGARALVGTGVSIALPAGYAAFVVPRSGLAAKHGITIVNSPGTVDAGYRGEIKVALLNTDQSEPFQIAPGDRIAQLIIMPVAQARFIPVDTLPGSARGEGGFGSTGTAPIGSATPTSGGIA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP014145
EMBL· GenBank· DDBJ
AMB58297.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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