A0A0X1TL20 · A0A0X1TL20_9FIRM

  • Protein
    Adenylosuccinate synthetase
  • Gene
    purA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13-19GTP (UniProtKB | ChEBI)
Active site14Proton acceptor
Binding site14Mg2+ (UniProtKB | ChEBI)
Binding site14-17IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site39-42IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site41Mg2+ (UniProtKB | ChEBI)
Binding site41-43GTP (UniProtKB | ChEBI)
Active site42Proton donor
Binding site128IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Active site139
Binding site142IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site222IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site237IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site297-303substrate
Binding site301IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site303GTP (UniProtKB | ChEBI)
Binding site329-331GTP (UniProtKB | ChEBI)
Binding site411-413GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • Name
      purA
    • ORF names
      AT726_06355

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • H121
  • Taxonomic lineage
    Bacteria > Bacillota > Erysipelotrichia > Erysipelotrichales > Turicibacteraceae > Turicibacter

Accessions

  • Primary accession
    A0A0X1TL20

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    426
  • Mass (Da)
    47,221
  • Last updated
    2016-04-13 v1
  • Checksum
    56574117FADFF91A
MAKTVVVVGTQWGDEGKGKITDYLAQQADIVARYQGGNNAGHTIEFNGQQFKLRLIPSGIFNSEKVILGNGMVINPESLLEEIAYLNEGGISTDHIRISNRAHVIFPYHIELDGLQEELKGDQKVGTTKRGIGPCYTDKYARVGIRMGELMDKEVFATRLKEQLADKNEILAKYGKPTFSFEEIYTKYCEYADVIRPYVTDTSYELDEAFNEDKKVLFEGAQGVMLDIDHGTYPFVTSSNPSAGAVTTGLGVGPTKIEEVIGVVKAYSTRVGEGAFPTEIEGEIANRIREIGREYGTVTGRPRRIGWFDSVVVSHTRRVSGLTGISVNLLDVLSGLETLKICTAYELDGQVIKYVPSTIKEFERCTPVYEEMPGWQEDITGVTSFEELPVAAQNYLRRIEELIGAKVAIFSVGPDREQTILLKALF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP013476
EMBL· GenBank· DDBJ
AMC08560.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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