A0A0X1KG61 · A0A0X1KG61_MOUSE
- ProteinE3 ubiquitin-protein ligase CBL
- GeneCbl
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids869 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphotyrosine residue binding | |
Molecular Function | ubiquitin-protein transferase activity | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of signaling |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase CBL
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A0X1KG61
Proteomes
Organism-specific databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-349 | Cbl-PTB | ||||
Sequence: PPCTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTG | ||||||
Domain | 379-418 | RING-type | ||||
Sequence: CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR | ||||||
Region | 428-460 | Disordered | ||||
Sequence: VVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDER | ||||||
Region | 474-683 | Disordered | ||||
Sequence: AKAASGSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGAETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSMTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPMPKLPPGEQGESEEDTEYMTPTSRPVGVQKPEPKRPLEATQSSRACD | ||||||
Compositional bias | 490-507 | Pro residues | ||||
Sequence: PPTLRDLPPPPPPDRPYS | ||||||
Compositional bias | 593-609 | Polar residues | ||||
Sequence: STFSLDTSMTMNSSPVA | ||||||
Compositional bias | 706-725 | Polar residues | ||||
Sequence: VAENSASGEGNLATAHTSTG | ||||||
Region | 706-743 | Disordered | ||||
Sequence: VAENSASGEGNLATAHTSTGPEESENEDDGYDVPKPPV | ||||||
Region | 770-819 | Disordered | ||||
Sequence: DPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGATANPVATAPSPQ | ||||||
Compositional bias | 795-819 | Polar residues | ||||
Sequence: ERKASSYQQGGGATANPVATAPSPQ | ||||||
Domain | 819-858 | UBA | ||||
Sequence: QLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREF |
Domain
The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length869
- Mass (Da)96,000
- Last updated2016-03-16 v1
- ChecksumE319E78BD850E65F
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P22682 | CBL_MOUSE | Cbl | 913 | ||
A0A0U1RQ85 | A0A0U1RQ85_MOUSE | Cbl | 896 | ||
A0A0U1RP95 | A0A0U1RP95_MOUSE | Cbl | 79 | ||
A0A0U1RNF1 | A0A0U1RNF1_MOUSE | Cbl | 69 | ||
A0A0U1RP47 | A0A0U1RP47_MOUSE | Cbl | 895 | ||
A0A0U1RP17 | A0A0U1RP17_MOUSE | Cbl | 51 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 490-507 | Pro residues | ||||
Sequence: PPTLRDLPPPPPPDRPYS | ||||||
Compositional bias | 593-609 | Polar residues | ||||
Sequence: STFSLDTSMTMNSSPVA | ||||||
Compositional bias | 706-725 | Polar residues | ||||
Sequence: VAENSASGEGNLATAHTSTG | ||||||
Compositional bias | 795-819 | Polar residues | ||||
Sequence: ERKASSYQQGGGATANPVATAPSPQ |
Keywords
- Technical term