A0A0W8I8U5 · A0A0W8I8U5_9MICO

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Active site74Proton acceptor
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site75substrate
Binding site163-166substrate
Binding site185substrate
Binding site190-191substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      AVL62_04890

Organism names

  • Taxonomic identifier
  • Strain
    • CD08_5
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Ornithinimicrobiaceae > Serinicoccus

Accessions

  • Primary accession
    A0A0W8I8U5

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    207
  • Mass (Da)
    21,555
  • Last updated
    2016-03-16 v1
  • Checksum
    5A9BD59275ACB5A0
MSRVVLATRNPGKVGELRDILAEALDRAGLELVGLDAFPDLEDVVESGVTFAQNALLKARYAAAATGLPALADDSGLAVDVLGGAPGIFSARWSGPLGEATGRTRDEANNDLLLAQLADVPEEHRGAGFVCAAALVLPGGQEVVREGRCRGTLGRAPRGTNGFGYDPLLVRPDGRTLAEHSSAEKHAVSHRGKAFRALGQDLAELLT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LQBL01000022
EMBL· GenBank· DDBJ
KUG55825.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp