A0A0W8GYC9 · A0A0W8GYC9_ACIJO
- ProteinRibose-phosphate pyrophosphokinase
- Geneprs
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids317 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Catalytic activity
- D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H+
Cofactor
Note: Binds 2 Mg2+ ions per subunit.
Pathway
Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 37-39 | ATP (UniProtKB | ChEBI) | |||
Binding site | 96-97 | ATP (UniProtKB | ChEBI) | |||
Binding site | 131 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 170 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 194 | ||||
Binding site | 196 | D-ribose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 220 | D-ribose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 224-228 | D-ribose 5-phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ribose phosphate diphosphokinase complex | |
Molecular Function | ATP binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | ribose phosphate diphosphokinase activity | |
Biological Process | 5-phosphoribose 1-diphosphate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibose-phosphate pyrophosphokinase
- EC number
- Short namesRPPK
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter
Accessions
- Primary accessionA0A0W8GYC9
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-121 | Ribose-phosphate pyrophosphokinase N-terminal | |||
Sequence similarities
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length317
- Mass (Da)34,357
- Last updated2016-03-16 v1
- ChecksumE4DBC7355FA0A3EE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP022298 EMBL· GenBank· DDBJ | AZN64879.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BJUJ01000125 EMBL· GenBank· DDBJ | GEK45576.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOECG010000001 EMBL· GenBank· DDBJ | MDG9785613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCDR010000003 EMBL· GenBank· DDBJ | MDH0655155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCCL010000003 EMBL· GenBank· DDBJ | MDH0825310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCBE010000001 EMBL· GenBank· DDBJ | MDH0968510.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCIL010000001 EMBL· GenBank· DDBJ | MDH1439224.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCLH010000001 EMBL· GenBank· DDBJ | MDH2171005.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QFQJ01000118 EMBL· GenBank· DDBJ | PZQ85565.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP065666 EMBL· GenBank· DDBJ | QPS04633.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RHXE01000002 EMBL· GenBank· DDBJ | RSE26926.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FUUY01000005 EMBL· GenBank· DDBJ | SJX22280.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFRV01000006 EMBL· GenBank· DDBJ | SUT96321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP121776 EMBL· GenBank· DDBJ | WMG18549.1 EMBL· GenBank· DDBJ | Genomic DNA |