A0A0W8GYC9 · A0A0W8GYC9_ACIJO

  • Protein
    Ribose-phosphate pyrophosphokinase
  • Gene
    prs
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site37-39ATP (UniProtKB | ChEBI)
Binding site96-97ATP (UniProtKB | ChEBI)
Binding site131Mg2+ (UniProtKB | ChEBI)
Binding site170Mg2+ (UniProtKB | ChEBI)
Active site194
Binding site196D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site220D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site224-228D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processphosphorylation
Biological Processpurine nucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      ACNJC6_01913
      , AJO04nite_28340
      , CFH90_12925
      , DI542_15925
      , EGT73_01370
      , I6G67_03860
      , N5C10_04225
      , N5C97_02095
      , N5D11_03340
      , N5I27_12915
      , N5J46_00850
      , N7566_01050
      , NCTC10308_01989
      , QBJ73_02725

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C6
    • IC001
    • S2_003_000_R3_20
    • NCTC10308
    • AJ_385
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A0W8GYC9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-121Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    317
  • Mass (Da)
    34,357
  • Last updated
    2016-03-16 v1
  • Checksum
    E4DBC7355FA0A3EE
MPNLVVFSGSAHPQFAQKVVSHLHIPLGAASIGQFSDGEIAVEITENVRGKDVFIVQPTCAPTNDNLMEILVMADALRRASAGRITAVIPYFGYARQDRRPRSSRVPITAKVVADMLTTVGIDRVVMIDLHADQIQGFFDIPVDNIYGTPALLADLRQQSHDNLMVVSPDVGGVVRARAVAKQMGDIDLAIIDKRRQKANESQVMHLIGDVKGRDCVIVDDMVDTAGTLCKAADALKTFGARKVVAYATHPVLSGKAIENLKNSVIDELVVTDTIPLSEEAQALGKIRQVSVASMVAETIRRINNEESISAMFDSYL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP022298
EMBL· GenBank· DDBJ
AZN64879.1
EMBL· GenBank· DDBJ
Genomic DNA
BJUJ01000125
EMBL· GenBank· DDBJ
GEK45576.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOECG010000001
EMBL· GenBank· DDBJ
MDG9785613.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCDR010000003
EMBL· GenBank· DDBJ
MDH0655155.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCCL010000003
EMBL· GenBank· DDBJ
MDH0825310.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCBE010000001
EMBL· GenBank· DDBJ
MDH0968510.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCIL010000001
EMBL· GenBank· DDBJ
MDH1439224.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCLH010000001
EMBL· GenBank· DDBJ
MDH2171005.1
EMBL· GenBank· DDBJ
Genomic DNA
QFQJ01000118
EMBL· GenBank· DDBJ
PZQ85565.1
EMBL· GenBank· DDBJ
Genomic DNA
CP065666
EMBL· GenBank· DDBJ
QPS04633.1
EMBL· GenBank· DDBJ
Genomic DNA
RHXE01000002
EMBL· GenBank· DDBJ
RSE26926.1
EMBL· GenBank· DDBJ
Genomic DNA
FUUY01000005
EMBL· GenBank· DDBJ
SJX22280.1
EMBL· GenBank· DDBJ
Genomic DNA
UFRV01000006
EMBL· GenBank· DDBJ
SUT96321.1
EMBL· GenBank· DDBJ
Genomic DNA
CP121776
EMBL· GenBank· DDBJ
WMG18549.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp