A0A0W4ZG66 · A0A0W4ZG66_PNEC8

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-17ITP (UniProtKB | ChEBI)
Binding site40Mg2+ (UniProtKB | ChEBI)
Binding site52ITP (UniProtKB | ChEBI)
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site68-69ITP (UniProtKB | ChEBI)
Binding site144-147ITP (UniProtKB | ChEBI)
Binding site167ITP (UniProtKB | ChEBI)
Binding site172-173ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      T552_02340

Organism names

Accessions

  • Primary accession
    A0A0W4ZG66

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    21,275
  • Last updated
    2016-03-16 v1
  • Checksum
    CED19357D94413E5
MSQILIYTAIVTGNIKKLKEIKEILGTTVKLTHVSLDLPEIQGEIHEIVLDKCKKAVDIVKKPVIIEDTSLFFTSFNGLPGPYIKWFLSSVGLDGLVRLLEAFPDKTAEAICLFAYCKGPGDTVHIFEGKTLGTIVPARGPTVFGWDAIFQPLDYDQTYAEMDQTLKHKISHRSKALTKLSEFLKHANNDV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LFVZ01000010
EMBL· GenBank· DDBJ
KTW27361.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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