A0A0W2HDI0 · A0A0W2HDI0_9ENTR
- ProteinATP-dependent Clp protease proteolytic subunit
- GeneclpP_2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids200 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Catalytic activity
- Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 99 | Nucleophile | |||
Active site | 124 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | endopeptidase Clp complex | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | ATPase binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent Clp protease proteolytic subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex
Accessions
- Primary accessionA0A0W2HDI0
Proteomes
Subcellular Location
Interaction
Subunit
Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
Structure
Sequence
- Sequence statusComplete
- Length200
- Mass (Da)22,305
- Last updated2016-03-16 v1
- MD5 Checksum8A54BBFB5307DDE44DAEF8227A0380E6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP023447 EMBL· GenBank· DDBJ | BCL41107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABJWE010000008 EMBL· GenBank· DDBJ | MBA2153919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAFKCP010000005 EMBL· GenBank· DDBJ | MBU3767028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NEYZ02000036 EMBL· GenBank· DDBJ | RNT44103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FKDK01000010 EMBL· GenBank· DDBJ | SAA72458.1 EMBL· GenBank· DDBJ | Genomic DNA |