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A0A0W2HDI0 · A0A0W2HDI0_9ENTR

  • Protein
    ATP-dependent Clp protease proteolytic subunit
  • Gene
    clpP_2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

Catalytic activity

  • Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
    EC:3.4.21.92 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

120020406080100120140160180200
TypeIDPosition(s)Description
Active site99Nucleophile
Active site124

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendopeptidase Clp complex
Molecular FunctionATP-dependent peptidase activity
Molecular FunctionATPase binding
Molecular Functionserine-type endopeptidase activity
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent Clp protease proteolytic subunit
  • EC number
  • Alternative names
    • Endopeptidase Clp

Gene names

    • Name
      clpP_2
    • Synonyms
      clpP
      , clpP_1
    • ORF names
      B9059_006405
      , HNS33_13760
      , J0A64_10525
      , OIPHN260_06090
      , SAMEA2273443_02725

Organism names

  • Taxonomic identifier
  • Strains
    • E2161
    • e2161
    • CRK0054
    • YK16
    • OIPH-N260
    • BK34275
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Enterobacter > Enterobacter cloacae complex

Accessions

  • Primary accession
    A0A0W2HDI0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

Family & Domains

Sequence similarities

Belongs to the peptidase S14 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    22,305
  • Last updated
    2016-03-16 v1
  • MD5 Checksum
    8A54BBFB5307DDE44DAEF8227A0380E6
MHYTLKESDKDKAEGSNGAGALQQKLLESRSIVISGEINQELAQKVITQMILLQSVSNDPIKLYINSQGGHVEAGDTIHDFIKFIRPEVHVIGTGWVASAGITIFLAAKKEHRYSLPNTRFMIHQPLGGVRGQATDIEIEAREIIRMLDRVNKLIADATGQPLEKVKKDTDRNFWMSPAEALDYGIVGKLITHYDELKLD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023447
EMBL· GenBank· DDBJ
BCL41107.1
EMBL· GenBank· DDBJ
Genomic DNA
JABJWE010000008
EMBL· GenBank· DDBJ
MBA2153919.1
EMBL· GenBank· DDBJ
Genomic DNA
JAFKCP010000005
EMBL· GenBank· DDBJ
MBU3767028.1
EMBL· GenBank· DDBJ
Genomic DNA
NEYZ02000036
EMBL· GenBank· DDBJ
RNT44103.1
EMBL· GenBank· DDBJ
Genomic DNA
FKDK01000010
EMBL· GenBank· DDBJ
SAA72458.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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