A0A0W0SUQ6 · A0A0W0SUQ6_9GAMM
- ProteinBranched-chain-amino-acid aminotransferase
- Geneala_2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids682 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts on leucine, isoleucine and valine.
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Catalytic activity
- 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate
Cofactor
Pathway
Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-isopropylmalate synthase activity | |
Molecular Function | L-isoleucine transaminase activity | |
Molecular Function | L-leucine transaminase activity | |
Molecular Function | L-leucine:2-oxoglutarate aminotransferase activity | |
Molecular Function | L-valine transaminase activity | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | L-leucine biosynthetic process | |
Biological Process | valine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBranched-chain-amino-acid aminotransferase
- EC number
- Short namesBCAT
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Legionellaceae > Legionella
Accessions
- Primary accessionA0A0W0SUQ6
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-271 | Pyruvate carboxyltransferase | ||||
Sequence: IIILDTTLRDGEQAPGATMTLSQKIEIACALDCMGVDIIEAGFAAASAGDFHCIEQISQVVKNATVCSLARAKIADIEAASSALKLAKKPRIHTFISTSDLHLKYQFKITQDEALVAIASSVQNARNLCDDVEWSAMDATRSHIDFLARAVEIAINAGASTINIPDTVGYTTPQEYSDLIQALKNKVPNIDKVILSVHCHNDLGLAVANSIAAINAGARQIECTINGIGERAGNAALEEIIMAIKTRSDQFPFAISVDSTHIA |
Sequence similarities
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length682
- Mass (Da)74,287
- Last updated2016-03-16 v1
- Checksum6BC44580B10FF51E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LNXY01000021 EMBL· GenBank· DDBJ | KTC87127.1 EMBL· GenBank· DDBJ | Genomic DNA |