A0A0W0DG71 · A0A0W0DG71_CANGB
- ProteinInosine triphosphate pyrophosphatase
- GeneHAM1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids192 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Catalytic activity
- H2O + ITP = diphosphate + H+ + IMP
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10-15 | ITP (UniProtKB | ChEBI) | ||||
Sequence: TGNANK | ||||||
Binding site | 43 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 56 | ITP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 74 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 74-75 | ITP (UniProtKB | ChEBI) | ||||
Sequence: DT | ||||||
Binding site | 149-152 | ITP (UniProtKB | ChEBI) | ||||
Sequence: FGWD | ||||||
Binding site | 173 | ITP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 178-179 | ITP (UniProtKB | ChEBI) | ||||
Sequence: HR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | dATP diphosphatase activity | |
Molecular Function | dCTP diphosphatase activity | |
Molecular Function | dGTP diphosphatase activity | |
Molecular Function | dITP diphosphatase activity | |
Molecular Function | dTTP diphosphatase activity | |
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | GTP diphosphatase activity | |
Molecular Function | ITP diphosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | UTP diphosphatase activity | |
Molecular Function | XTP diphosphatase activity | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine deoxyribonucleoside triphosphate catabolic process | |
Biological Process | pyrimidine deoxyribonucleoside triphosphate catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine triphosphate pyrophosphatase
- EC number
- Short namesITPase ; Inosine triphosphatase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Nakaseomyces
Accessions
- Primary accessionA0A0W0DG71
Proteomes
Organism-specific databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length192
- Mass (Da)21,433
- Last updated2016-03-16 v1
- Checksum1ED9E0055476536A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LLZZ01000022 EMBL· GenBank· DDBJ | KTB12358.1 EMBL· GenBank· DDBJ | Genomic DNA |