A0A0V0Y3Z0 · A0A0V0Y3Z0_TRIPS
- ProteinFanconi-associated nuclease
- Genefan-1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids523 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | 5'-3' exonuclease activity | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | flap-structured DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphodiesterase I activity | |
Biological Process | interstrand cross-link repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFanconi-associated nuclease
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Enoplea > Dorylaimia > Trichinellida > Trichinellidae > Trichinella
Accessions
- Primary accessionA0A0V0Y3Z0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-28 | Helical | ||||
Sequence: IALSFLMMCNLLFFLLFTCSLQL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 371-485 | VRR-NUC | ||||
Sequence: LSVQDIQSMLRASWREHEGINSIVKWDAFESSEMLEEILSCMDGRMLVKLFGRLASNFKRHSSGFPDLVVWNVQSRDIKVAEVKGPGDRLSWKQKAWLSHFIKSGIHAEVCLVKG | ||||||
Region | 502-523 | Disordered | ||||
Sequence: RGRKRVHGEEEEEEEDIFDNHN |
Sequence similarities
Belongs to the FAN1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length523
- Mass (Da)60,812
- Last updated2016-03-16 v1
- ChecksumC0C0B74746413258
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0V0Y2D7 | A0A0V0Y2D7_TRIPS | fan-1 | 730 | ||
A0A0V0Y2D3 | A0A0V0Y2D3_TRIPS | fan-1 | 321 | ||
A0A0V0Y300 | A0A0V0Y300_TRIPS | fan-1 | 442 | ||
A0A0V0Y2Q3 | A0A0V0Y2Q3_TRIPS | fan-1 | 513 | ||
A0A0V0Y315 | A0A0V0Y315_TRIPS | fan-1 | 443 | ||
A0A0V0Y1X5 | A0A0V0Y1X5_TRIPS | fan-1 | 453 | ||
A0A0V0Y273 | A0A0V0Y273_TRIPS | fan-1 | 622 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: L |
Keywords
- Technical term