A0A0V0Y3Z0 · A0A0V0Y3Z0_TRIPS

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Function5'-3' exonuclease activity
Molecular Function5'-flap endonuclease activity
Molecular Functionflap-structured DNA binding
Molecular Functionmetal ion binding
Molecular Functionphosphodiesterase I activity
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • Name
      fan-1
    • ORF names
      T4E_1877

Organism names

Accessions

  • Primary accession
    A0A0V0Y3Z0

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-28Helical

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain371-485VRR-NUC
Region502-523Disordered

Sequence similarities

Belongs to the FAN1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    523
  • Mass (Da)
    60,812
  • Last updated
    2016-03-16 v1
  • Checksum
    C0C0B74746413258
LRNWEIALSFLMMCNLLFFLLFTCSLQLKCRQTLQLILEVIYTMRLVSLNLQKTPLSKPGIRKEKLFSSDGELMKYVSVCELENEMWNCWNSKKYTVCLHVGSRIRHLLDEELRLLSEKPCSVRLVHYQNFTAIVSLLRASTVLAQAFEKLKMYDKANAEFEHLISIDCQLAPAHRRSFWYERAILNYGRHLKLPKKAFELAADVIQDNTFDYYFRQRIYDRVMQMNLVDEDCEKQLAANIQTALDETIEIDVEIPEKVISALLLSKSMGTSVKTVFVIPQEHQFSCPNVEAVALNYYHQEEHFSKGLHSEGSVWLALFGLLCWNEIYDSTVEDVWISRYQTYPLDLYVGEMFWINRQKTFEKKFETLQCLSVQDIQSMLRASWREHEGINSIVKWDAFESSEMLEEILSCMDGRMLVKLFGRLASNFKRHSSGFPDLVVWNVQSRDIKVAEVKGPGDRLSWKQKAWLSHFIKSGIHAEVCLVKGCSSKALSTATVNATLSRGRKRVHGEEEEEEEDIFDNHN

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0V0Y2D7A0A0V0Y2D7_TRIPSfan-1730
A0A0V0Y2D3A0A0V0Y2D3_TRIPSfan-1321
A0A0V0Y300A0A0V0Y300_TRIPSfan-1442
A0A0V0Y2Q3A0A0V0Y2Q3_TRIPSfan-1513
A0A0V0Y315A0A0V0Y315_TRIPSfan-1443
A0A0V0Y1X5A0A0V0Y1X5_TRIPSfan-1453
A0A0V0Y273A0A0V0Y273_TRIPSfan-1622

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JYDU01000072
EMBL· GenBank· DDBJ
KRX94409.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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